ethyl 4-(4-(1-chloroethyl)-2-methoxy-5-nitrophenoxy)butanoate

Base Information

• Chemical Name: ethyl 4-(4-(1-chloroethyl)-2-methoxy-5-nitrophenoxy)butanoate
• CAS No.: 1285712-73-3
• Molecular Formula: C₁₅H₂₀ClNO₆
• Molecular Weight: 345.78
• Mol file: 1285712-73-3.mol

Synonyms:ethyl 4-(4-(1-chloroethyl)-2-methoxy-5-nitrophenoxy)butanoate

Chemical Property of ethyl 4-(4-(1-chloroethyl)-2-methoxy-5-nitrophenoxy)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(4-(1-chloroethyl)-2-methoxy-5-nitrophenoxy)butanoate

There total 5 articles about ethyl 4-(4-(1-chloroethyl)-2-methoxy-5-nitrophenoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy) butanoate (1073426-06-8) → ethyl 4-(4-(1-chloroethyl)-2-methoxy-5-nitrophenoxy)butanoate (1285712-73-3)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2020.127291

Reference yield:

ethyl 4-(4-acetyl-2-methoxyphenoxy) butanoate (174884-21-0) → ethyl 4-(4-(1-chloroethyl)-2-methoxy-5-nitrophenoxy)butanoate (1285712-73-3)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid / acetic anhydride / 3 h / 0 °C

2: sodium tetrahydroborate / methanol / 3 h / 0 - 20 °C

3: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; nitric acid; In methanol; dichloromethane; acetic anhydride;

DOI:10.1039/c0cc05274d

Reference yield:

ethyl 4-(4-acetyl-2-methoxy-5-nitrophenoxy)butanoate (1031702-80-3) → ethyl 4-(4-(1-chloroethyl)-2-methoxy-5-nitrophenoxy)butanoate (1285712-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 3 h / 0 - 20 °C

2: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane;

DOI:10.1039/c0cc05274d

upstream raw materials:

ethyl 4-(4-acetyl-2-methoxy-5-nitrophenoxy)butanoate

ethyl 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy) butanoate

Ethyl 4-bromobutyrate

1-(3-methoxy-4-hydroxyphenyl)ethanone

Downstream raw materials:

ethyl 4-(4-(1-azidoethyl)-2-methoxy-5-nitrophenoxy)butanoate

4-(4-(1-azidoethyl)-2-methoxy-5-nitrophenoxy)butanoic acid

4-(4-acetyl-2-methoxy-5-nitrophenoxy)butanoic acid

ethyl 4-(4-acetyl-2-methoxy-5-nitrophenoxy)butanoate