N-(3-chloro-4-(4-methyl-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide

Base Information

Chemical Name:N-(3-chloro-4-(4-methyl-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide
CAS No.:1218926-22-7
Molecular Formula:C₂₁H₁₄ClN₃O₃
Molecular Weight:391.813
Hs Code.:

Synonyms:N-(3-chloro-4-(4-methyl-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-chloro-4-(4-methyl-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide

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Technology Process of N-(3-chloro-4-(4-methyl-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide

There total 5 articles about N-(3-chloro-4-(4-methyl-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 4792-30-7
3-methylphthalic acid anhydride

: 1308655-78-8
N-(3-chloro-4-aminophenyl)-2-picolinamide

: 1218926-22-7
N-(3-chloro-4-(4-methyl-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide

Guidance literature:: With acetic acid; at 100 ℃; for 5h;
DOI:10.1021/jm501245b

Reference yield:

: N-(3-chloro-4-nitrophenyl)-2-picolinamide

: 1218926-22-7
N-(3-chloro-4-(4-methyl-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 20 h / 20 °C / 2280.15 Torr

2: acetic acid / 5 h / 100 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; ethyl acetate;
DOI:10.1021/jm501245b

Reference yield:

: 29745-44-6
pyridine-2-carbonyl chloride

: 1218926-22-7
N-(3-chloro-4-(4-methyl-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / Reflux

2: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 20 h / 20 °C / 2280.15 Torr

3: acetic acid / 5 h / 100 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jm501245b