(2R,8aR)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one

Base Information

• Chemical Name: (2R,8aR)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one
• CAS No.: 1034128-48-7
• Molecular Formula: C₂₁H₂₁NO₃
• Molecular Weight: 335.403

Synonyms:(2R,8aR)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one

Chemical Property of (2R,8aR)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one

Chemical Property:

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Technology Process of (2R,8aR)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one

There total 11 articles about (2R,8aR)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(3R,5R)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate (1034128-52-3) → (2R,8aR)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one (1034128-48-7) + (2R,8aS)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one (1034128-54-5)

Guidance literature:

With methanol; potassium hydroxide; at 65 ℃; for 4h;

DOI:10.1016/j.bmcl.2012.03.109

Reference yield:

(2S,4R)-4-(hydroxy)-2-(2-[4-methoxyphenyl]-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidine (1034128-45-4) → (2R,8aR)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one (1034128-48-7) + (2R,8aS)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one (1034128-54-5)

Guidance literature:

With potassium hydroxide; In methanol; for 4h; Heating;

DOI:10.1016/j.bmc.2008.02.073

Reference yield:

(3R,5S)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate (1034128-46-5) → (2R,8aR)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one (1034128-48-7) + (2R,8aS)-2-hydroxy-7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5-(1H)-one (1034128-54-5)

Guidance literature:

With potassium hydroxide; In methanol; for 4h; Heating;

DOI:10.1016/j.bmc.2008.02.073

upstream raw materials:

(2S,4R)-4-(hydroxy)-2-(2-[4-methoxyphenyl]-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidine

(3R,5S)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate

(3R,5R)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate

[1-(4-methoxyphenyl)vinyloxy]trimethylsilane

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