(3R,5S)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate

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Chemical Name:(3R,5S)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate
CAS No.:1034128-46-5
Molecular Formula:C₂₃H₂₅NO₅
Molecular Weight:395.455
Hs Code.:

Synonyms:(3R,5S)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate

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Chemical Property of (3R,5S)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate

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Technology Process of (3R,5S)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate

There total 7 articles about (3R,5S)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 55991-65-6
[1-(4-methoxyphenyl)vinyloxy]trimethylsilane

: 1375570-79-8
(2S,4R)-4-(acetoxy)-1-(2-phenylacetyl)proline

: 1034128-46-5
(3R,5S)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate

: 1034128-52-3
(3R,5R)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate

Guidance literature:: (2S,4R)-4-(acetoxy)-1-(2-phenylacetyl)proline; With [bis(acetoxy)iodo]benzene; iodine; In dichloromethane; at 26 ℃; for 3h; Inert atmosphere; Irradiation;

[1-(4-methoxyphenyl)vinyloxy]trimethylsilane; With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 1.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.03.109

Reference yield:

: 103-82-2
phenylacetic acid

: C₁₅H₁₉NO₄*ClH

: 1034128-46-5
(3R,5S)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate

: 1034128-52-3
(3R,5R)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate

Guidance literature:: With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -15 ℃; for 2h;
DOI:10.1016/j.bmc.2008.02.073

Reference yield:

: benzyl (2S,4R)-4-(hydroxy)-1-(2-phenylacetyl)proline

: 1034128-46-5
(3R,5S)-5-(2-(4-methoxyphenyl)-2-oxoethyl)-1-(2-phenylacetyl)pyrrolidin-3-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 12 h / 0 - 26 °C

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h

3.1: [bis(acetoxy)iodo]benzene; iodine / dichloromethane / 3 h / 26 °C / Inert atmosphere; Irradiation

3.2: 1.5 h / 0 °C / Inert atmosphere

With pyridine; [bis(acetoxy)iodo]benzene; palladium 10% on activated carbon; hydrogen; iodine; In dichloromethane; ethyl acetate;
DOI:10.1016/j.ejmech.2013.06.009