(2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde

Base Information

• Chemical Name: (2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde
• CAS No.: 1304774-20-6
• Molecular Formula: C₁₈H₂₀N₂O₃S
• Molecular Weight: 344.434

Synonyms:(2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde

Chemical Property of (2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde

Chemical Property:

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Technology Process of (2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde

There total 7 articles about (2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

tert-butyl (2S,4S)-4-(4-methylbenzenesulfonyl)amino-5-oxo-1-phenylprolinate (1304774-14-8) → (2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde (1304774-20-6) + (2S,4S)-2-hydroxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine (1304774-17-1) + tert-butyl (2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylprolinate (1304774-16-0)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at -5 - 0 ℃; for 168.5h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201100049

Reference yield: 38.0%

tert-butyl (2S,4S)-4-(4-methylbenzenesulfonyl)amino-5-oxo-1-phenylprolinate (1304774-14-8) → (2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde (1304774-20-6) + (2S,4S)-2-hydroxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine (1304774-17-1) + (2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine (1304774-19-3)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 25 ℃; for 168.5h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201100049

Reference yield: 25.0%

tert-butyl (2S,4S)-4-(4-methylbenzenesulfonyl)amino-5-oxo-1-phenylprolinate (1304774-14-8) → (2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde (1304774-20-6) + (2S,4S)-2-hydroxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine (1304774-17-1) + (2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine (1304774-19-3) + tert-butyl (2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylprolinate (1304774-16-0)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at -5 - 0 ℃; for 840.5h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201100049

upstream raw materials:

(2S,4S)-4-[(4-methylbenzenesulfonyl)amino]-5-oxo-1-phenylproline

tert-butyl (2S,4S)-4-(4-methylbenzenesulfonyl)amino-5-oxo-1-phenylprolinate

methyl (2S,4S)-4-(4-methylbenzenesulfonyl)amino-5-oxo-1-phenylprolinate

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