(2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine

Base Information

Chemical Name:(2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine
CAS No.:1304774-19-3
Molecular Formula:C₂₂H₃₀N₂O₃S
Molecular Weight:402.558
Hs Code.:

Synonyms:(2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine

Suppliers and Price of (2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine

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Technology Process of (2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine

There total 3 articles about (2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1304774-14-8
tert-butyl (2S,4S)-4-(4-methylbenzenesulfonyl)amino-5-oxo-1-phenylprolinate

: 1304774-20-6
(2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde

: 1304774-17-1
(2S,4S)-2-hydroxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine

: 1304774-19-3
(2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 25 ℃; for 168.5h; chemoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201100049

Reference yield: 25.0%

: 1304774-14-8
tert-butyl (2S,4S)-4-(4-methylbenzenesulfonyl)amino-5-oxo-1-phenylprolinate

: 1304774-20-6
(2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde

: 1304774-17-1
(2S,4S)-2-hydroxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine

: 1304774-19-3
(2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine

: 1304774-16-0
tert-butyl (2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylprolinate

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; at -5 - 0 ℃; for 840.5h; chemoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201100049

Reference yield:

: 1032764-52-5
(2S,4S)-4-[(4-methylbenzenesulfonyl)amino]-5-oxo-1-phenylproline

: 1304774-20-6
(2S,4S)-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine-2-carbaldehyde

: 1304774-17-1
(2S,4S)-2-hydroxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine

: 1304774-19-3
(2S,4S)-2-tert-butyloxymethyl-4-(4-methylbenzenesulfonyl)amino-1-phenylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / dichloromethane / 24 h / -18 °C

2: dimethylsulfide borane complex / tetrahydrofuran / 168.5 h / 0 - 25 °C / Inert atmosphere

With dimethylsulfide borane complex; sulfuric acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201100049