(S)-1,1-dimethylethyl 2-<<4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-1-pyrrolidinecarboxylate

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Chemical Name:(S)-1,1-dimethylethyl 2-<<4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-1-pyrrolidinecarboxylate
CAS No.:135697-18-6
Molecular Formula:C₂₁H₂₄N₄O₅
Molecular Weight:412.445
Hs Code.:

Synonyms:(S)-1,1-dimethylethyl 2-<<4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-1-pyrrolidinecarboxylate

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Chemical Property of (S)-1,1-dimethylethyl 2-<<4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-1-pyrrolidinecarboxylate

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Technology Process of (S)-1,1-dimethylethyl 2-<<4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-1-pyrrolidinecarboxylate

There total 6 articles about (S)-1,1-dimethylethyl 2-<<4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 98-88-4
benzoyl chloride

: 135697-16-4
(S)-1,1-dimethylethyl 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methyl>-5-oxo-1-pyrrolidinecarboxylate

: 135697-18-6
(S)-1,1-dimethylethyl 2-<<4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-1-pyrrolidinecarboxylate

Guidance literature:: With pyridine; for 8h; Ambient temperature;
DOI:10.1021/jo00021a010

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 135697-18-6
(S)-1,1-dimethylethyl 2-<<4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / N-methylimidazole / CH₂Cl₂ / 24 h / 0 °C

2: 62 percent / potassium tert-butoxide / dimethylsulfoxide / 18 h / 25 °C

3: dimethylformamide / 8 h / 40 °C

4: 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂

5: 79 percent / (p-toluenesulfonyl)hydrazine / CH₂Cl₂ / 24 h / 25 °C

6: 70 percent / pyridine / 8 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; dmap; potassium tert-butylate; triethylamine; toluene-4-sulfonic acid hydrazide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo00021a010

Reference yield:

: 51693-17-5
(S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester

: 135697-18-6
(S)-1,1-dimethylethyl 2-<<4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / potassium tert-butoxide / dimethylsulfoxide / 18 h / 25 °C

2: dimethylformamide / 8 h / 40 °C

3: 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂

4: 79 percent / (p-toluenesulfonyl)hydrazine / CH₂Cl₂ / 24 h / 25 °C

5: 70 percent / pyridine / 8 h / Ambient temperature

With pyridine; dmap; potassium tert-butylate; triethylamine; toluene-4-sulfonic acid hydrazide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo00021a010