4-amino-α3-(3-chlorophenyl)-α1-(4-chlorophenyl)-α1-(1-methyl-1H-imidazol-5-yl)-1,3-benzenedimethanol

Base Information

Chemical Name:4-amino-α3-(3-chlorophenyl)-α1-(4-chlorophenyl)-α1-(1-methyl-1H-imidazol-5-yl)-1,3-benzenedimethanol
CAS No.:432553-05-4
Molecular Formula:C₂₄H₂₁Cl₂N₃O₂
Molecular Weight:454.356
Hs Code.:

Synonyms:4-amino-α3-(3-chlorophenyl)-α1-(4-chlorophenyl)-α1-(1-methyl-1H-imidazol-5-yl)-1,3-benzenedimethanol

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Chemical Property of 4-amino-α3-(3-chlorophenyl)-α1-(4-chlorophenyl)-α1-(1-methyl-1H-imidazol-5-yl)-1,3-benzenedimethanol

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Technology Process of 4-amino-α3-(3-chlorophenyl)-α1-(4-chlorophenyl)-α1-(1-methyl-1H-imidazol-5-yl)-1,3-benzenedimethanol

There total 6 articles about 4-amino-α3-(3-chlorophenyl)-α1-(4-chlorophenyl)-α1-(1-methyl-1H-imidazol-5-yl)-1,3-benzenedimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 192187-40-9
(+/-)-[2-amino-5-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]phenyl](3-chlorophenyl)methanone

: 432553-05-4
4-amino-α3-(3-chlorophenyl)-α1-(4-chlorophenyl)-α1-(1-methyl-1H-imidazol-5-yl)-1,3-benzenedimethanol

Guidance literature:: With sodium tetrahydroborate; In methanol;
DOI:10.1016/S0960-894X(03)00180-X

Reference yield:

: 190898-64-7
2-(4-Chlorophenyl)-2-(4-nitrophenyl)-1,3-dioxolane

: 432553-05-4
4-amino-α3-(3-chlorophenyl)-α1-(4-chlorophenyl)-α1-(1-methyl-1H-imidazol-5-yl)-1,3-benzenedimethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaOH / methanol

2.1: aq. HCl

3.1: n-BuLi; ClSiEt₃ / tetrahydrofuran / -70 °C

3.2: 58 percent / n-BuLi / tetrahydrofuran / -70 °C

4.1: 69 percent / H₂O; TiCl₃ / tetrahydrofuran / 5 °C

5.1: NaBH₄ / methanol

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; titanium(III) chloride; triethylsilyl chloride; water; In tetrahydrofuran; methanol;
DOI:10.1016/S0960-894X(03)00180-X

Reference yield:

: 190898-77-2
3-(3-chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-2,1-benzisoxazole

: 432553-05-4
4-amino-α3-(3-chlorophenyl)-α1-(4-chlorophenyl)-α1-(1-methyl-1H-imidazol-5-yl)-1,3-benzenedimethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. HCl

2.1: n-BuLi; ClSiEt₃ / tetrahydrofuran / -70 °C

2.2: 58 percent / n-BuLi / tetrahydrofuran / -70 °C

3.1: 69 percent / H₂O; TiCl₃ / tetrahydrofuran / 5 °C

4.1: NaBH₄ / methanol

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; titanium(III) chloride; triethylsilyl chloride; water; In tetrahydrofuran; methanol;
DOI:10.1016/S0960-894X(03)00180-X