190898-64-7Relevant articles and documents
Streamlined processes for the synthesis of a farnesyl transferase inhibitor drug candidate
Andresen, Brian M.,Couturier, Michel,Cronin, Brian,D'Occhio, Michael,Ewing, Marcus D.,Guinn, Mark,Hawkins, Joel M.,Jasys, V. John,LaGreca, Susan D.,Lyssikatos, Joseph P.,Moraski, Garrett,Ng, Karl,Raggon, Jeffrey W.,Stewart, A. Morgan,Tickner, Derek L.,Tucker, John L.,Urban, Frank J.,Vazquez, Enrique,Wei, Lulin
, p. 643 - 650 (2013/09/02)
As part of a fast-paced oncology program, quinolinone 1 was discovered and developed as a potent inhibitor of farnesyl transferase for the treatment of cancer. The initial synthesis, which suffered from a lengthy linear sequence and a late-stage chromatog
5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors
Angibaud, Patrick,Bourdrez, Xavier,Devine, Ann,End, David W.,Freyne, Eddy,Ligny, Yannick,Muller, Philippe,Mannens, Geert,Pilatte, Isabelle,Poncelet, Virginie,Skrzat, Stacy,Smets, Gerda,Van Dun, Jacky,Van Remoortere, Pieter,Venet, Marc,Wouters, Walter
, p. 1543 - 1547 (2007/10/03)
The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.
Farnesyltransferase inhibiting quinazolinones
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, (2008/06/13)
This invention concerns compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; R1and R2eac