192187-40-9

Basic information

• Product Name: (+/-)-[2-amino-5-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]phenyl](3-chlorophenyl)methanone
• Synonyms: (+/-)-[2-amino-5-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]phenyl](3-chlorophenyl)methanone
• CAS NO: 192187-40-9
• Molecular Weight: 452.34
• Mol File: 192187-40-9.mol

Chemical Properties

• CAS DataBase Reference: (+/-)-[2-amino-5-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]phenyl](3-chlorophenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-[2-amino-5-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]phenyl](3-chlorophenyl)methanone(192187-40-9)
• EPA Substance Registry System: (+/-)-[2-amino-5-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]phenyl](3-chlorophenyl)methanone(192187-40-9)

Safety Data

• Hazardous Substances Data: 192187-40-9(Hazardous Substances Data)

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 192187-38-5 (4-chlorophenyl)[3-(3-chlorophenyl)-2,1-benzisoxazol-5-yl]methanone 
• 190898-77-2 3-(3-chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-2,1-benzisoxazole 
• 190898-64-7 2-(4-Chlorophenyl)-2-(4-nitrophenyl)-1,3-dioxolane 
• 7497-60-1 (4-Chlorophenyl)(4-nitrophenyl)methanone 
• 192187-39-6 (+/-)-3-(3-chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-2,1-benzisoxazole-5-methanol 

Downstream Products

• 280143-21-7 (+/-)-4-(3-chlorophenyl)-α-(4chlorophenyl)-2-methyl-α-(1-methyl-1H-imidazol-5-yl)-6-quinolinemethanol 
• 432553-08-7 2-bromo-N-[2-(3-chlorobenzoyl)-4-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]phenyl]-acetamide 
• 432553-06-5 2-bromo-N-[2-[(3-chlorophenyl)hydroxymethyl]4-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]phenyl]-acetamide 
• 432552-78-8 5-(3-chlorophenyl)-7-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1,5-dihydro-4,1-benzothiazepin-2(3H)-one 
• 432552-79-9 5-(3-chlorophenyl)-7-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1,5-dihydro-1-methyl-4,1-benzoxazepin-2(3H)-one 
• 432552-87-9 7-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-5-(3-chlorophenyl)-1,5-dihydro-1-methyl-4,1-benzothiazepin-2(3H)-one 
• 432552-82-4 5-(3-chlorophenyl)-7-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1,5-dihydro-1-methyl-4,1-benzothiazepin-2(3H)-one 
• 432553-32-7 7-[chloro(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-5-(3-chlorophenyl)-1,5-dihydro-1-methyl-4,1-benzothiazepin-2(3H)-one 
• 432552-77-7 5-(3-chlorophenyl)-7-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1,5-dihydro-4,1-benzoxazepin-2(3H)-one 
• 280143-54-6 (4-chloro-phenyl)-[5-(3-chloro-phenyl)-[1,2,3]triazolo[1,5-a]quinolin-7-yl]-(3-methyl-3H-imidazol-4-yl)-methanol 
• 280143-22-8 4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-quinoline-2-carbaldehyde 
• 744187-30-2 7-[chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-[1,2,3]triazolo[1,5-a]quinoline 
• 432553-05-4 4-amino-α3-(3-chlorophenyl)-α1-(4-chlorophenyl)-α1-(1-methyl-1H-imidazol-5-yl)-1,3-benzenedimethanol 

Relevant articles and documents

5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors

The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.

Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quionlinone derivatives

PCT No. PCT/EP96/04515 Sec. 371 Date May 26, 1998 Sec. 102(e) Date May 26, 1998 PCT Filed Oct. 16, 1996 PCT Pub. No. WO97/21701 PCT Pub. Date Jun. 19, 1997This invention comprises the novel compounds of formula (I) wherein the dotted line represents an op