(3-bromo-2,5-difluorophenyl)methanol

Base Information

• Chemical Name: (3-bromo-2,5-difluorophenyl)methanol
• CAS No.: 1159186-56-7
• Molecular Formula: C₇H₅BrF₂O
• Molecular Weight: 223.017
• Hs Code.: 2934999090
• Mol file: 1159186-56-7.mol

Synonyms:(3-bromo-2,5-difluorophenyl)methanol

Chemical Property of (3-bromo-2,5-difluorophenyl)methanol

Chemical Property:

• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(3-Bromo-2,5-difluorophenyl)methanol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-bromo-2,5-difluorophenyl)methanol

There total 3 articles about (3-bromo-2,5-difluorophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-2,5-difluorobenzaldehyde (112279-64-8) → (3-bromo-2,5-difluorophenyl)methanol (1159186-56-7)

Guidance literature:

3-bromo-2,5-difluorobenzaldehyde; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

With water; In tetrahydrofuran;

Reference yield:

4-amino-3-bromo-2,5-difluorobenzonitrile (112279-62-6) → (3-bromo-2,5-difluorophenyl)methanol (1159186-56-7)

Guidance literature:

Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 20 h / -78 - 20 °C

2: hypophosphorous acid; sodium nitrite / water; acetic acid / 0 - 20 °C

3: methanol; sodium tetrahydroborate / 0.17 h / 20 °C

With methanol; sodium tetrahydroborate; hypophosphorous acid; diisobutylaluminium hydride; sodium nitrite; In tetrahydrofuran; water; acetic acid; toluene;

Reference yield:

4-amino-3-bromo-2,5-difluorobenzaldehyde (112279-63-7) → (3-bromo-2,5-difluorophenyl)methanol (1159186-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hypophosphorous acid; sodium nitrite / water; acetic acid / 0 - 20 °C

2: methanol; sodium tetrahydroborate / 0.17 h / 20 °C

With methanol; sodium tetrahydroborate; hypophosphorous acid; sodium nitrite; In water; acetic acid;

upstream raw materials:

3-bromo-2,5-difluorobenzaldehyde

4-amino-3-bromo-2,5-difluorobenzonitrile

4-amino-3-bromo-2,5-difluorobenzaldehyde

Downstream raw materials:

1-bromo-3-(chloromethyl)-2,5-difluorobenzene

C₂₂H₂₁F₂N₇O₃

4-(3-(bromomethyl)-2,5-difluorophenyl)morpholin-3-one

4-(3-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-2,5-difluorophenyl)morpholin-3-one

Refernces

• 1、 -. "PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS". Page/Page column 92. . Retrieved 2009/07/03.