4-(3-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-2,5-difluorophenyl)morpholin-3-one

Base Information

Chemical Name:4-(3-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-2,5-difluorophenyl)morpholin-3-one
CAS No.:1421857-71-7
Molecular Formula:C₁₇H₁₃ClF₂N₄O₂
Molecular Weight:378.766
Hs Code.:

Synonyms:4-(3-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-2,5-difluorophenyl)morpholin-3-one

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Chemical Property of 4-(3-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-2,5-difluorophenyl)morpholin-3-one

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Technology Process of 4-(3-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-2,5-difluorophenyl)morpholin-3-one

There total 6 articles about 4-(3-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-2,5-difluorophenyl)morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1206979-33-0
6-chloro-1H-pyrazolo[4,3-c]pyridine

: 1296311-13-1
4-(3-(bromomethyl)-2,5-difluorophenyl)morpholin-3-one

: 1421857-71-7
4-(3-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-2,5-difluorophenyl)morpholin-3-one

Guidance literature:: With potassium carbonate; In acetonitrile; at 60 ℃; for 18h;

Reference yield:

: 112279-63-7
4-amino-3-bromo-2,5-difluorobenzaldehyde

: 1421857-71-7
4-(3-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-2,5-difluorophenyl)morpholin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: hypophosphorous acid; sodium nitrite / water; acetic acid / 0 - 20 °C

2: methanol; sodium tetrahydroborate / 0.17 h / 20 °C

3: copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; potassium carbonate / 1,4-dioxane / 16 h / 100 °C

4: phosphorus tribromide / dichloromethane / 16 h / 20 °C

5: potassium carbonate / acetonitrile / 18 h / 60 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; hypophosphorous acid; phosphorus tribromide; potassium carbonate; sodium nitrite; In 1,4-dioxane; dichloromethane; water; acetic acid; acetonitrile;

Reference yield:

: 112279-64-8
3-bromo-2,5-difluorobenzaldehyde

: 1421857-71-7
4-(3-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-2,5-difluorophenyl)morpholin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; sodium tetrahydroborate / 0.17 h / 20 °C

2: copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; potassium carbonate / 1,4-dioxane / 16 h / 100 °C

3: phosphorus tribromide / dichloromethane / 16 h / 20 °C

4: potassium carbonate / acetonitrile / 18 h / 60 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; phosphorus tribromide; potassium carbonate; In 1,4-dioxane; dichloromethane; acetonitrile;