N-(4-methyl-3-(2-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenylamino)phenyl)propane-1-sulfonamide

Base Information

Chemical Name:N-(4-methyl-3-(2-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenylamino)phenyl)propane-1-sulfonamide
CAS No.:1437316-90-9
Molecular Formula:C₂₆H₃₀N₆O₃S
Molecular Weight:506.629
Hs Code.:

Synonyms:N-(4-methyl-3-(2-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenylamino)phenyl)propane-1-sulfonamide

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Chemical Property of N-(4-methyl-3-(2-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenylamino)phenyl)propane-1-sulfonamide

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Technology Process of N-(4-methyl-3-(2-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenylamino)phenyl)propane-1-sulfonamide

There total 7 articles about N-(4-methyl-3-(2-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenylamino)phenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1437316-89-6
2-(9-(tetrahydro-2-hydropyran-2-yl)-9H-purin-6-yl)aniline

: 1274065-83-6
N-(3-bromo-4-methylbenzene-yl)propane-1-sulfonamide

: 1437316-90-9
N-(4-methyl-3-(2-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenylamino)phenyl)propane-1-sulfonamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In toluene; at 80 ℃; for 20h; Inert atmosphere;

Reference yield:

: 191171-55-8
2-anilineboronic acid pinacol ester

: 1437316-90-9
N-(4-methyl-3-(2-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenylamino)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 0.25 h / 170 °C / Inert atmosphere; Microwave irradiation

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / toluene / 20 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; caesium carbonate; XPhos; In water; toluene; acetonitrile;

Reference yield:

: 615-36-1
2-bromoaniline

: 1437316-90-9
N-(4-methyl-3-(2-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenylamino)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 15 h / 80 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 0.25 h / 170 °C / Inert atmosphere; Microwave irradiation

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / toluene / 20 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; caesium carbonate; XPhos; In 1,4-dioxane; water; toluene; acetonitrile;