ethyl 2-(4-fluoro-2-iodobenzyl)-2-amino-3-(4-fluoro-2-iodophenyl)propanoate

Base Information

Chemical Name:ethyl 2-(4-fluoro-2-iodobenzyl)-2-amino-3-(4-fluoro-2-iodophenyl)propanoate
CAS No.:1394350-78-7
Molecular Formula:C₁₈H₁₇F₂I₂NO₂
Molecular Weight:571.144
Hs Code.:

Synonyms:ethyl 2-(4-fluoro-2-iodobenzyl)-2-amino-3-(4-fluoro-2-iodophenyl)propanoate

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Chemical Property of ethyl 2-(4-fluoro-2-iodobenzyl)-2-amino-3-(4-fluoro-2-iodophenyl)propanoate

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Technology Process of ethyl 2-(4-fluoro-2-iodobenzyl)-2-amino-3-(4-fluoro-2-iodophenyl)propanoate

There total 2 articles about ethyl 2-(4-fluoro-2-iodobenzyl)-2-amino-3-(4-fluoro-2-iodophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394351-48-4
C₁₉H₁₅F₂I₂NO₂

: 1394350-78-7
ethyl 2-(4-fluoro-2-iodobenzyl)-2-amino-3-(4-fluoro-2-iodophenyl)propanoate

Guidance literature:: With hydrogenchloride; water; In ethanol; at 20 ℃;
DOI:10.1021/ja306631z

Reference yield:

: 70931-59-8
1-(bromomethyl)-4-fluoro-2-iodobenzene

: 1394350-78-7
ethyl 2-(4-fluoro-2-iodobenzyl)-2-amino-3-(4-fluoro-2-iodophenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / 0 - 70 °C

2: water; hydrogenchloride / ethanol / 20 °C

With hydrogenchloride; water; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In ethanol; acetonitrile;
DOI:10.1021/ja306631z

Reference yield: 81.0%

: 1394350-78-7
ethyl 2-(4-fluoro-2-iodobenzyl)-2-amino-3-(4-fluoro-2-iodophenyl)propanoate

: 1394351-09-7
(S)-ethyl 2-(4-fluoro-2-iodobenzyl)-6-fluoroindoline-2-carboxylate

Guidance literature:: With copper(l) iodide; (Ra)-3,3’-di(anthracen-9-yl)-[1,1’-binaphthalene]-2,2’-diol; caesium carbonate; In 1,4-dioxane; at 20 ℃; for 10h; enantioselective reaction;
DOI:10.1021/ja306631z