diethyl [4-(3'-formyl-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate

Base Information

Chemical Name:diethyl [4-(3'-formyl-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate
CAS No.:852949-21-4
Molecular Formula:C₂₃H₃₁O₇P
Molecular Weight:450.469
Hs Code.:

Synonyms:diethyl [4-(3'-formyl-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate

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Chemical Property of diethyl [4-(3'-formyl-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate

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Technology Process of diethyl [4-(3'-formyl-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate

There total 6 articles about diethyl [4-(3'-formyl-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 852949-20-3
5-(4-hydroxy-2,6-dimethylbenzyl)-2-methoxymethoxybenzaldehyde

: 106938-62-9
(diethoxyphosphinyl)methyl trifluoromethanesulfonate

: 852949-21-4
diethyl [4-(3'-formyl-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 852949-17-8
(2,6-dimethyl-4-triisopropylsilanyloxyphenyl)-(4-methoxymethoxyphenyl)methanol

: 852949-21-4
diethyl [4-(3'-formyl-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 5 h / 20 °C / 760.05 Torr

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; diethyl ether / 1 h / -20 - 0 °C

2.2: 2 h / 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 6515-21-5
4-methoxymethoxy-benzaldehyde

: 852949-21-4
diethyl [4-(3'-formyl-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 5 h / 20 °C / 760.05 Torr

3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; diethyl ether / 1 h / -20 - 0 °C

3.2: 2 h / 0 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetic acid; ethyl acetate; N,N-dimethyl-formamide;