(6aS,8S,10aS,10bR)-8-Benzyloxy-6a-(3,4-dimethoxy-phenyl)-decahydro-oxazolo[4,3-a]isoquinolin-3-one

Base Information

Chemical Name:(6aS,8S,10aS,10bR)-8-Benzyloxy-6a-(3,4-dimethoxy-phenyl)-decahydro-oxazolo[4,3-a]isoquinolin-3-one
CAS No.:104072-40-4
Molecular Formula:C₂₆H₃₁NO₅
Molecular Weight:437.536
Hs Code.:

Synonyms:(6aS,8S,10aS,10bR)-8-Benzyloxy-6a-(3,4-dimethoxy-phenyl)-decahydro-oxazolo[4,3-a]isoquinolin-3-one

Suppliers and Price of (6aS,8S,10aS,10bR)-8-Benzyloxy-6a-(3,4-dimethoxy-phenyl)-decahydro-oxazolo[4,3-a]isoquinolin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (6aS,8S,10aS,10bR)-8-Benzyloxy-6a-(3,4-dimethoxy-phenyl)-decahydro-oxazolo[4,3-a]isoquinolin-3-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (6aS,8S,10aS,10bR)-8-Benzyloxy-6a-(3,4-dimethoxy-phenyl)-decahydro-oxazolo[4,3-a]isoquinolin-3-one

There total 2 articles about (6aS,8S,10aS,10bR)-8-Benzyloxy-6a-(3,4-dimethoxy-phenyl)-decahydro-oxazolo[4,3-a]isoquinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104072-38-0
3-[(E)-3-(3,4-Dimethoxy-phenyl)-octa-3,7-dienyl]-oxazolidine-2,4-dione

: 104072-40-4
(6aS,8S,10aS,10bR)-8-Benzyloxy-6a-(3,4-dimethoxy-phenyl)-decahydro-oxazolo[4,3-a]isoquinolin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaBH₄ / 1.) MeOH, 0 deg C, 10 min; 2.) 3 h, r.t.

2: 1.) 3N NaOH; 2.) NaH, 18-crown-6 / 1.) MeOH, r.t; 2.) THF, DMF

With sodium hydroxide; sodium tetrahydroborate; 18-crown-6 ether; sodium hydride;
DOI:10.1021/ja00281a047

Reference yield:

: 100-39-0
benzyl bromide

: 104072-39-1
6a-(3',4'-dimethoxyphenyl)oxazoloisoquinolin-8-formate

: 104072-40-4
(6aS,8S,10aS,10bR)-8-Benzyloxy-6a-(3,4-dimethoxy-phenyl)-decahydro-oxazolo[4,3-a]isoquinolin-3-one

Guidance literature:: With sodium hydroxide; 18-crown-6 ether; sodium hydride; Yield given. Multistep reaction; 1.) MeOH, r.t; 2.) THF, DMF;
DOI:10.1021/ja00281a047

Reference yield:

: 104072-40-4
(6aS,8S,10aS,10bR)-8-Benzyloxy-6a-(3,4-dimethoxy-phenyl)-decahydro-oxazolo[4,3-a]isoquinolin-3-one

: 104072-43-7
(1S,4aS,6S,8aS)-6-Benzyloxy-4a-(3,4-dimethoxy-phenyl)-1-formyl-octahydro-isoquinoline-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 8percent KOH / 1.) EtOH, reflux

2: Et₃N, (COCl)2 / dimethylsulfoxide

3: 79.2 percent / t-BuOK / diethyl ether / 2 h / -25 °C

With potassium hydroxide; oxalyl dichloride; potassium tert-butylate; triethylamine; In diethyl ether; dimethyl sulfoxide;
DOI:10.1021/ja00281a047