6a-(3',4'-dimethoxyphenyl)oxazoloisoquinolin-8-formate

Base Information

Chemical Name:6a-(3',4'-dimethoxyphenyl)oxazoloisoquinolin-8-formate
CAS No.:104072-39-1
Molecular Formula:C₂₀H₂₅NO₆
Molecular Weight:375.422
Hs Code.:

Synonyms:6a-(3',4'-dimethoxyphenyl)oxazoloisoquinolin-8-formate

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Chemical Property of 6a-(3',4'-dimethoxyphenyl)oxazoloisoquinolin-8-formate

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Technology Process of 6a-(3',4'-dimethoxyphenyl)oxazoloisoquinolin-8-formate

There total 1 articles about 6a-(3',4'-dimethoxyphenyl)oxazoloisoquinolin-8-formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-18-6
formic acid

: 104072-38-0
3-[(E)-3-(3,4-Dimethoxy-phenyl)-octa-3,7-dienyl]-oxazolidine-2,4-dione

: 104072-39-1
6a-(3',4'-dimethoxyphenyl)oxazoloisoquinolin-8-formate

Guidance literature:: With sodium tetrahydroborate; Yield given. Multistep reaction; 1.) MeOH, 0 deg C, 10 min; 2.) 3 h, r.t.;
DOI:10.1021/ja00281a047

Reference yield:

: 104072-39-1
6a-(3',4'-dimethoxyphenyl)oxazoloisoquinolin-8-formate

: 104072-46-0
C₂₆H₃₃NO₄

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) 3N NaOH; 2.) NaH, 18-crown-6 / 1.) MeOH, r.t; 2.) THF, DMF

2: 1.) 8percent KOH / 1.) EtOH, reflux

3: Et₃N, (COCl)2 / dimethylsulfoxide

4: 79.2 percent / t-BuOK / diethyl ether / 2 h / -25 °C

5: 1.) BF₃*Et₂O; 2.) Jones reagent / 1.) toluene, -15 deg C, 0.5 h; 2.) acetone, 0 deg C, 5 min

6: LiALH₄ / tetrahydrofuran

With potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; jones reagent; oxalyl dichloride; 18-crown-6 ether; boron trifluoride diethyl etherate; potassium tert-butylate; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1021/ja00281a047

Reference yield:

: 104072-39-1
6a-(3',4'-dimethoxyphenyl)oxazoloisoquinolin-8-formate

: 104072-42-6
(1R,4aS,6S,8aS)-6-Benzyloxy-4a-(3,4-dimethoxy-phenyl)-1-formyl-octahydro-isoquinoline-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 3N NaOH; 2.) NaH, 18-crown-6 / 1.) MeOH, r.t; 2.) THF, DMF

2: 1.) 8percent KOH / 1.) EtOH, reflux

3: Et₃N, (COCl)2 / dimethylsulfoxide

With potassium hydroxide; sodium hydroxide; oxalyl dichloride; 18-crown-6 ether; sodium hydride; triethylamine; In dimethyl sulfoxide;
DOI:10.1021/ja00281a047