tert-butyl (3R)-3-[(4-(S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl]-6-(3-methyl-4-phenylphenyl)hexanoate

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Chemical Name:tert-butyl (3R)-3-[(4-(S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl]-6-(3-methyl-4-phenylphenyl)hexanoate
CAS No.:230962-35-3
Molecular Formula:C₃₄H₃₉NO₅
Molecular Weight:541.687
Hs Code.:

Synonyms:tert-butyl (3R)-3-[(4-(S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl]-6-(3-methyl-4-phenylphenyl)hexanoate

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Chemical Property of tert-butyl (3R)-3-[(4-(S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl]-6-(3-methyl-4-phenylphenyl)hexanoate

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Technology Process of tert-butyl (3R)-3-[(4-(S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl]-6-(3-methyl-4-phenylphenyl)hexanoate

There total 13 articles about tert-butyl (3R)-3-[(4-(S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl]-6-(3-methyl-4-phenylphenyl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 230962-34-2
4-(S)-benzyl-3-{5-(3-methyl-4-phenylphenyl)pentanoyl}oxazolidin-2-one

: 230962-35-3
tert-butyl (3R)-3-[(4-(S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl]-6-(3-methyl-4-phenylphenyl)hexanoate

Guidance literature:: 4-(S)-benzyl-3-{5-(3-methyl-4-phenylphenyl)pentanoyl}oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -75 ℃; for 1h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at -70 - -50 ℃;
DOI:10.1021/jm0308038

Reference yield:

: 108-55-4
glutaric anhydride,

: 230962-35-3
tert-butyl (3R)-3-[(4-(S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl]-6-(3-methyl-4-phenylphenyl)hexanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Mg; I₂ / tetrahydrofuran / Heating

1.2: 60 percent / tetrahydrofuran / -40 - 0 °C

2.1: Et₃SiH; TFA / 0 - 20 °C

3.1: (COCl)2; DMF / CH₂Cl₂ / -10 - 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -70 - -50 °C

4.2: 91 percent / tetrahydrofuran; hexane / -70 - 0 °C

5.1: NaN(SiMe₃)2 / tetrahydrofuran / 1 h / -75 °C

5.2: 61 percent / tetrahydrofuran / -70 - -50 °C

With triethylsilane; n-butyllithium; oxalyl dichloride; iodine; sodium hexamethyldisilazane; magnesium; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm0308038

Reference yield:

: 5002-26-6
3-methyl-4-phenylbromobenzene

: 230962-35-3
tert-butyl (3R)-3-[(4-(S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl]-6-(3-methyl-4-phenylphenyl)hexanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Mg; I₂ / tetrahydrofuran / Heating

1.2: 60 percent / tetrahydrofuran / -40 - 0 °C

2.1: Et₃SiH; TFA / 0 - 20 °C

3.1: (COCl)2; DMF / CH₂Cl₂ / -10 - 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -70 - -50 °C

4.2: 91 percent / tetrahydrofuran; hexane / -70 - 0 °C

5.1: NaN(SiMe₃)2 / tetrahydrofuran / 1 h / -75 °C

5.2: 61 percent / tetrahydrofuran / -70 - -50 °C

With triethylsilane; n-butyllithium; oxalyl dichloride; iodine; sodium hexamethyldisilazane; magnesium; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm0308038