5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine

Base Information

Chemical Name:5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine
CAS No.:130867-57-1
Molecular Formula:C₃₄H₃₆N₂O₉
Molecular Weight:616.668
Hs Code.:

Synonyms:5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine

Chemical Property:

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Technology Process of 5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine

There total 2 articles about 5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19500-95-9
Methoxyacetic anhydride

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 130867-57-1
5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine

Guidance literature:

Reference yield:

: 38870-89-2
Methoxyacetyl chloride

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 130867-57-1
5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine

Guidance literature:: With pyridine;

Reference yield:

: 130867-57-1
5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine

: 130867-65-1
C₃₈H₄₀N₄O₁₄

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-diisopropylethylamine (DIPEA) / pyridine / 1 h / Ambient temperature

2: 85 percent / 90percent aq. acetic acid / 0.5 h / 50 °C

3: 44 percent / N-iodosuccinimide (NIS), molecular sieves (5 Angstroem) / TfOH / 1,2-dichloro-ethane; diethyl ether / 0.17 h / 0 °C

4: 78 percent / hydrazine, acetic acid / pyridine; ethyl acetate / 0.02 h / Ambient temperature

With N-iodo-succinimide; 5A molecular sieve; acetic acid; N-ethyl-N,N-diisopropylamine; hydrazine; trifluorormethanesulfonic acid; In pyridine; diethyl ether; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4020(01)86429-2