(Z)-1-acetyl-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

Base Information

• Chemical Name: (Z)-1-acetyl-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione
• CAS No.: 120040-35-9
• Molecular Formula: C₂₅H₂₈N₂O₇
• Molecular Weight: 468.507
• Mol file: 120040-35-9.mol

Synonyms:(Z)-1-acetyl-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

Chemical Property of (Z)-1-acetyl-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-acetyl-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

There total 1 articles about (Z)-1-acetyl-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-1-acetyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione (113296-74-5) + p-methoxybenzyl chloride (824-94-2) → (Z)-1-acetyl-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione (120040-35-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 30 min; 2.) DMF, 25 deg C, 12 h;

DOI:10.1248/cpb.36.2607

Reference yield: 50.2%

(Z)-1-acetyl-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione (120040-35-9) → (Z)-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione (120040-36-0)

Guidance literature:

With hydrazine hydrate; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

DOI:10.1248/cpb.36.2607

Reference yield:

(Z)-1-acetyl-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione (120040-35-9) → 1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione (120040-38-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 50.2 percent / hydrazine hydrate / dimethylformamide / 1 h / 25 °C

2: 1.) sodium hydride / 1.) DMF, 0 deg C, 30 min; 2.) DMF, 25 deg C, 1 h

3: 69 percent / H₂SO₄ / trifluoroacetic acid / 12 h / 25 °C

4: 68.3 percent / hydrogen / 20percent palladium on carbon / ethanol / 4 h / 760 Torr

With sulfuric acid; hydrogen; sodium hydride; hydrazine hydrate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1248/cpb.36.2607

upstream raw materials:

(Z)-1-acetyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

p-methoxybenzyl chloride

Downstream raw materials:

(Z)-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

(Z)-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

6-Hydroxy-4-methyl-3-oxo-2-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazine-1-carboxylic acid isopropyl ester