ethyl 1-(4-bromophenyl)-3-(butylamino)-2,5-dihydro-2-oxo-1H-pyrrole-4-carboxylate

Base Information

Chemical Name:ethyl 1-(4-bromophenyl)-3-(butylamino)-2,5-dihydro-2-oxo-1H-pyrrole-4-carboxylate
CAS No.:1443430-35-0
Molecular Formula:C₁₇H₂₁BrN₂O₃
Molecular Weight:381.269
Hs Code.:

Synonyms:ethyl 1-(4-bromophenyl)-3-(butylamino)-2,5-dihydro-2-oxo-1H-pyrrole-4-carboxylate

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Chemical Property of ethyl 1-(4-bromophenyl)-3-(butylamino)-2,5-dihydro-2-oxo-1H-pyrrole-4-carboxylate

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Technology Process of ethyl 1-(4-bromophenyl)-3-(butylamino)-2,5-dihydro-2-oxo-1H-pyrrole-4-carboxylate

There total 3 articles about ethyl 1-(4-bromophenyl)-3-(butylamino)-2,5-dihydro-2-oxo-1H-pyrrole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 109-73-9,85404-21-3
N-butylamine

: 106-40-1
4-bromo-aniline

: 762-21-0
acetylenedicarboxylic acid diethyl ester

: 1443430-35-0
ethyl 1-(4-bromophenyl)-3-(butylamino)-2,5-dihydro-2-oxo-1H-pyrrole-4-carboxylate

Guidance literature:: N-butylamine; acetylenedicarboxylic acid diethyl ester; In ethanol; for 0.5h; Green chemistry;

formaldehyd; 4-bromo-aniline; With N,N,N’,N’-tetramethyl-N,N’-bis(sulfo)ethane-1,2-diaminium mesylate; In ethanol; at 20 ℃; for 2.5h; Green chemistry;
DOI:10.1177/1747519819883881

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1081529-27-2
diethyl 2-(butylamino)but-2-enedioate

: 106-40-1
4-bromo-aniline

: 1443430-35-0
ethyl 1-(4-bromophenyl)-3-(butylamino)-2,5-dihydro-2-oxo-1H-pyrrole-4-carboxylate

Guidance literature:: With oxalic acid; In methanol; at 20 ℃; for 2h;
DOI:10.3184/174751912X13547952669204

Reference yield:

: 762-21-0
acetylenedicarboxylic acid diethyl ester

: 1443430-35-0
ethyl 1-(4-bromophenyl)-3-(butylamino)-2,5-dihydro-2-oxo-1H-pyrrole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 0.5 h

2: oxalic acid / methanol / 2 h / 20 °C

With oxalic acid; In methanol;
DOI:10.3184/174751912X13547952669204