N-(2-Carbamoyl-3-methoxyphenyl)oxamidic acid ethyl ester

Base Information

• Chemical Name: N-(2-Carbamoyl-3-methoxyphenyl)oxamidic acid ethyl ester
• CAS No.: 54249-44-4
• Molecular Formula: C12H14N2O5
• Molecular Weight: 266.254
• Hs Code.: 2924299090
• Mol file: 54249-44-4.mol

Synonyms:Wy 16,922;2'-Carbamoyl-3'-methoxy-oxanilic acid ethyl ester;Ethyl ((2-(aminocarbonyl)-3-methoxyphenyl)amino)oxoacetate;2'-Carbamoyl-3'-methoxy-oxanilsaeure-ethylester;2'-Carbamyl-3'-methoxyoxanilic acid ethyl ester;[2-(aminocarbonyl)-3-methoxyphenylamino]oxoacetic acid ethyl ester;Acetic acid,((2-(aminocarbonyl)-3-methoxyphenyl)amino)oxo-,ethyl ester;

Chemical Property of N-(2-Carbamoyl-3-methoxyphenyl)oxamidic acid ethyl ester

Chemical Property:

• PSA: 108.71000
• Density: 1.319g/cm³
• LogP: 1.25290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-Carbamoyl-3-methoxyphenyl)oxamidic acid ethyl ester

There total 7 articles about N-(2-Carbamoyl-3-methoxyphenyl)oxamidic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-6-methoxybenzamide (1591-38-4) + Ethyl oxalyl chloride (4755-77-5) → ethyl ((2-(aminocarbonyl)-3-methoxyphenyl)amino)(oxo)acetate (54249-44-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 35 ℃; for 2h; Cooling with ice;

Reference yield:

2,6-dinitrobenzoic acid (603-12-3) → ethyl ((2-(aminocarbonyl)-3-methoxyphenyl)amino)(oxo)acetate (54249-44-4)

Guidance literature:

Multi-step reaction with 4 steps

1: TsNH₂, PCl₅ / 185 - 187 °C

2: methanol

3: aq. N₂H₄ / Raney-Ni / ethanol

4: Py / CH₂Cl₂

With pyridine; phosphorus pentachloride; toluene-4-sulfonamide; hydrazine hydrate; nickel; In methanol; ethanol; dichloromethane;

DOI:10.1021/jm00243a014

Reference yield:

2-methoxy-6-nitrobenzonitrile (38469-85-1) → ethyl ((2-(aminocarbonyl)-3-methoxyphenyl)amino)(oxo)acetate (54249-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. N₂H₄ / Raney-Ni / ethanol

2: Py / CH₂Cl₂

With pyridine; hydrazine hydrate; nickel; In ethanol; dichloromethane;

DOI:10.1021/jm00243a014

upstream raw materials:

2-amino-6-methoxybenzamide

Ethyl oxalyl chloride

2,6-dinitrobenzoic acid

2-methoxy-6-nitrobenzonitrile

Downstream raw materials:

2'-carbamoyl-3'-methoxyoxanilic acid

N-(2-Carbamoyl-3-methoxyphenyl)oxamide