P-Chlorobenzyl phenyl ether

Base Information

• Chemical Name: P-Chlorobenzyl phenyl ether
• CAS No.: 19962-25-5
• Molecular Formula: C13H11ClO
• Molecular Weight: 218.683
• UNII: CP4609XW5I
• DSSTox Substance ID: DTXSID30173756
• Nikkaji Number: J293.119B
• Wikidata: Q27275594
• Mol file: 19962-25-5.mol

Synonyms:P-CHLOROBENZYL PHENYL ETHER;4-chlorobenzyl phenyl ether;19962-25-5;Ether, p-chlorobenzyl phenyl;Benzene, 1-chloro-4-(phenoxymethyl)-;(4-Chlorobenzyloxy)benzene;UNII-CP4609XW5I;CP4609XW5I;HSDB 2836;1-chloro-4-(phenoxymethyl)benzene;SCHEMBL5441069;DTXSID30173756;LKFFIBFCNOEEAU-UHFFFAOYSA-N;AKOS002959495;ETHER, P-CHLOROBENZYL PHENYL [HSDB];Q27275594

Chemical Property of P-Chlorobenzyl phenyl ether

Chemical Property:

• Vapor Pressure: 0.000676mmHg at 25°C
• Boiling Point: 318.4°C at 760 mmHg
• Flash Point: 147.5°C
• Density: 1.175g/cm³
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 218.0498427
• Heavy Atom Count: 15
• Complexity: 169

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Halogenated Polyaromatics
• Canonical SMILES: C1=CC=C(C=C1)OCC2=CC=C(C=C2)Cl

Technology Process of P-Chlorobenzyl phenyl ether

There total 13 articles about P-Chlorobenzyl phenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-Chloro-4-(chloromethyl)benzene (104-83-6) + phenol (108-95-2,27073-41-2) → 1-chloro-4-(phenoxymethyl)benzene (19962-25-5)

Guidance literature:

With potassium carbonate; In ethanol; at 78 ℃; for 5h;

Reference yield: 95.0%

iodobenzene (591-50-4) + para-Chlorobenzyl alcohol (873-76-7) → 1-chloro-4-(phenoxymethyl)benzene (19962-25-5)

Guidance literature:

With potassium hydroxide; at 60 ℃; for 0.5h; Catalytic behavior; Green chemistry;

DOI:10.1016/j.jorganchem.2019.05.011

Reference yield: 93.0%

chlorobenzene (108-90-7) + para-Chlorobenzyl alcohol (873-76-7) → 1-chloro-4-(phenoxymethyl)benzene (19962-25-5)

Guidance literature:

With potassium hydroxide; at 60 ℃; for 0.5h; Catalytic behavior; Green chemistry;

DOI:10.1016/j.jorganchem.2019.05.011

upstream raw materials:

4-chlorobenzyl fluoride

sodium phenoxide

1-Chloro-4-(chloromethyl)benzene

4-chlorobenzaldehyde

Downstream raw materials:

4-chlorobenzaldehyde

phenol

(5,10,15,20-tetrakis(p-tolyl)porphyrinato)(benzyl)iridium(III)

(p-chlorobenzyl)(5,10,15,20-tetrakis(p-tolyl)porphyrinato)iridium(III)

Refernces

• 1、 Mohammadinezhad, Arezou,Akhlaghinia, Batool. "CoII Immobilized on Aminated Magnetic-Based Metal–Organic Framework: An Efficient Heterogeneous Nanostructured Catalyst for the C–O Cross-Coupling Reaction in Solvent-Free Conditions". . p. 332 - 352. Retrieved 2020/01/11.
• 2、 Ming, Xiao-Xia,Tian, Ze-Yu,Zhang, Cheng-Pan. "Base-Mediated O-Arylation of Alcohols and Phenols by Triarylsulfonium Triflates". supporting information. p. 3370 - 3379. Retrieved 2019/11/03.