<(1S)-endo>-(-)-borneol S(P)-methyl phenyl phosphinate ester

Base Information

• Chemical Name: <(1S)-endo>-(-)-borneol S(P)-methyl phenyl phosphinate ester
• CAS No.: 136891-26-4
• Molecular Formula: C₁₇H₂₅O₂P
• Molecular Weight: 292.358
• Mol file: 136891-26-4.mol

Synonyms:<(1S)-endo>-(-)-borneol S(P)-methyl phenyl phosphinate ester

Chemical Property of <(1S)-endo>-(-)-borneol S(P)-methyl phenyl phosphinate ester

Chemical Property:

Purity/Quality:

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Technology Process of <(1S)-endo>-(-)-borneol S(P)-methyl phenyl phosphinate ester

There total 2 articles about <(1S)-endo>-(-)-borneol S(P)-methyl phenyl phosphinate ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

endo-borneol (464-45-9) + methyl(phenyl)phosphinic chloride (5761-97-7) → <(1S)-endo>-(-)-borneol S(P)-methyl phenyl phosphinate ester (136891-26-4) + <(1S)-endo>-(-)-borneol R(P)-methyl phenyl phosphinate ester (136835-32-0)

Guidance literature:

With dmap; In diethyl ether; for 16h; Ambient temperature;

DOI:10.1055/s-1991-26537

Reference yield:

endo-borneol (464-45-9) + methyl methylphenylphosphinate (6389-79-3) → <(1S)-endo>-(-)-borneol S(P)-methyl phenyl phosphinate ester (136891-26-4) + <(1S)-endo>-(-)-borneol R(P)-methyl phenyl phosphinate ester (136835-32-0)

Guidance literature:

endo-borneol; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere; Schlenk technique;

methyl methylphenylphosphinate; In tetrahydrofuran; at -78 - 20 ℃; for 5h; Inert atmosphere; Schlenk technique; Resolution of racemate;

DOI:10.1055/s-0037-1609947

upstream raw materials:

endo-borneol

methyl(phenyl)phosphinic chloride

methyl methylphenylphosphinate