Betamethasone 17-valerate

Base Information

• Chemical Name: Betamethasone 17-valerate
• CAS No.: 2152-44-5
• Molecular Formula: C27H37FO6
• Molecular Weight: 476.586
• Hs Code.: 2937229000
• NSC Number: 755912
• Mol file: 2152-44-5.mol

Synonyms:Pregna-1,4-diene-3,20-dione,9-fluoro-11b,17,21-trihydroxy-16b-methyl-, 17-valerate (7CI,8CI);9a-Fluoro-16b-methylprednisolone 17-valerate;Beta-Val;Betamethasone valerate;Betnesol V;Betnovate;Betoid;Bextasol;Celestan V;Celestoderm;Celeston valerate;Dermovaleas;Fuciderm;Rinderon V;Tokuderm;b-Methasone 17-valerate;

Chemical Property of Betamethasone 17-valerate

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 7.72E-17mmHg at 25°C
• Melting Point: 183-184oC
• Refractive Index: 1.56
• Boiling Point: 598.9 °C at 760 mmHg
• PKA: 12.90±0.70(Predicted)
• Flash Point: 316 °C
• PSA: 100.90000
• Density: 1.24 g/cm³
• LogP: 3.63680
• Storage Temp.: 2-8°C
• Solubility.: Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 476.25741706
• Heavy Atom Count: 34
• Complexity: 957

Purity/Quality:

99% ^*data from raw suppliers

Betamethasone 17-valerate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 48
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CO
• Isomeric SMILES: CCCCC(=O)O[C@@]1([C@H](CC2[C@@]1(CC([C@]3(C2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CO
• Uses: Betamethasone 17-Valerate is a corticosteroid with anti-inflammatory properties. Topical application of Betamethasone 17-Valerate has been shown to inhibit heat-induced vasodilatation in man. Antiepileptic non-selective phosphodiesterase inhibitor Betamethasone 17-valerate is a glucocorticoid with anti-inflammatory and immunosuppressive activity. A potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties
• Indications: Betamethasone valerate (Psorion, Beta-Val, Luxiq) is a synthetic fluorinated corticosteroid.
• Therapeutic Function: Corticosteroid

Technology Process of Betamethasone 17-valerate

There total 7 articles about Betamethasone 17-valerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ betamethasone-valerate (2152-44-5)

Guidance literature:

Reference yield:

→ Betamethason-17-valerianat (2152-44-5,33755-46-3)

Guidance literature:

Betamethason-17,21-divalerianat, H2SO4 aq. / MeOH;

Reference yield:

aqueous perchloric acid + 9α-fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-valerate 21-acetate (5919-89-1) → betamethasone-valerate (2152-44-5)

Guidance literature:

In methanol;

upstream raw materials:

trimethyl orthovalerate

betamethasone

9α-fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-valerate 21-acetate

Downstream raw materials:

9α-fluoro-11β-hydroxy-16β-methyl-21-phenylthio-17α-valeryloxy-1,4-pregnadiene-3,20-dione

Refernces

• 1、 -. "Composition for the topical treatment of poison ivy and other forms of contact dermatitis". . . Retrieved 2008/06/13.
• 2、 Mitsukuchi,Ikemoto,Taguchi,Higuchi,Abe,Yasui,Hatayama,Sota. "Studies on topical antiinflammatory agents. III. Synthesis of 17α-acyloxy-9α-fluoro-11β-hydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-thio derivatives and related compounds". . p. 3286 - 3293. Retrieved 2007/10/02.