9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Base Information Edit

Chemical Name:9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS No.:378-44-9
Molecular Formula:C22H29FO5
Molecular Weight:392.468
Hs Code.:HASONE ACETATE PRODUCT IDENTIFICATION
NSC Number:39470
Wikidata:Q27165596
ChEMBL ID:CHEMBL1393513
Mol file:378-44-9.mol

Synonyms:Elacridar;GF 120918;GF-120918;GF120918;GF120918A;GG918;N-(4-(2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide

Suppliers and Price of 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Betamethasone
500mg
$ 240.00

TCI Chemical
Betamethasone
1G
$ 64.00

TCI Chemical
Betamethasone
5G
$ 187.00

Sigma-Aldrich
Betamethasone meets USP testing specifications
25mg
$ 95.60

Sigma-Aldrich
Betamethasone Pharmaceutical Secondary Standard; Certified Reference Material
1g
$ 86.10

Sigma-Aldrich
Betamethasone ≥98%
500mg
$ 656.00

Sigma-Aldrich
Betamethasone meets USP testing specifications
100mg
$ 321.00

Sigma-Aldrich
Betamethasone United States Pharmacopeia (USP) Reference Standard
200mg
$ 366.00

Sigma-Aldrich
Betamethasone ≥98%
100mg
$ 191.00

Sigma-Aldrich
Betamethasone European Pharmacopoeia (EP) Reference Standard
b1000000
$ 190.00

Total 272 raw suppliers

Chemical Property of 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione Edit

Chemical Property:

Appearance/Colour:white to off-white solid
Vapor Pressure:2.81E-15mmHg at 25°C
Melting Point:235-237 °C
Refractive Index:118 ° (C=1, Dioxane)
Boiling Point:568.2 °C at 760 mmHg
PKA:12.13±0.70(Predicted)
Flash Point:297.5 °C
PSA：94.83000
Density:1.32 g/cm³
LogP:1.89570
Storage Temp.:0-6°C
Solubility.:Practically insoluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in methylene chloride.
Water Solubility.:58mg/L(25 oC)
XLogP3:1.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:392.19990218
Heavy Atom Count:28
Complexity:805

Purity/Quality:

99% ^*data from raw suppliers

Betamethasone ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi,Xn
Hazard Codes:Xi,Xn,T
Statements: 40-48/20/21-61
Safety Statements: 22-36-45-53

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Uses Hormone drugs.It is mainly used for anti-inflammatory and anti-allergic. It is suitable for rheumatoid arthritis and various skin diseases. Betamethasone role is similiar to dexamethasone, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone and it has few side effects. glucocorticoid, antiinflammatory Betamethasone is a glucocorticoid used as an anti-inflammatory agent. anti-inflammatory, immunosuppressive
production method According to U.S. Patent No. 3,164,618, betamethasone acetate is dealt with hydrochloric acid in methanol-chloroform-water mixture , it can be converted to betamethasone.
Description Shortly after the introduction of dexamethasone, betamethasone, which differs from dexamethasone only in configuration of the 16-methyl group, was made available for the treatment of rheumatic diseases and dermatologic disorders. This analogue, which contains a 16β-methyl group, has received sufficient clinical trial examination to indicate that it is as effective as dexamethasone or, perhaps, even slightly more active. Although this drug has been reported to be less toxic than other steroids, some clinical investigators suggest that it is best used for short-term therapy. Betamethasone is a synthetic corticosteroid. Like other corticosteroids, betamethasone has anti-inflammatory actions. Betamethasone also accelerates fetal lung maturation and has been used to decrease neonatal mortality and morbidity in infants born before 34 weeks of gestation.
Therapeutic Function Glucocorticoid
Clinical Use Corticosteroid: Suppression of inflammatory and allergic disorders Congenital adrenal hyperplasia
Drug interactions Potentially hazardous interactions with other drugs Aldesleukin: avoid concomitant use. Antibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycin; concentration of isoniazid possibly reduced. Anticoagulants: efficacy of coumarins and phenindione may be altered. Antiepileptics: metabolism accelerated by carbamazepine, fosphenytoin, phenobarbital, phenytoin and primidone. Antifungals: increased risk of hypokalaemia with amphotericin - avoid; metabolism possibly inhibited by itraconazole and ketoconazole. Antivirals: concentration possibly increased by ritonavir. Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroids. Cobicistat: concentration of betamethasone possibly increased. Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diuretics. Vaccines: high dose corticosteroids can impair immune response to vaccines; avoid with live vaccines.

Technology Process of 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

There total 35 articles about 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%