2-chloro-5-[3,6-dihydro-6-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-2(1H)-yl]benzoic acid

Base Information

Chemical Name:2-chloro-5-[3,6-dihydro-6-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-2(1H)-yl]benzoic acid
CAS No.:635325-28-9
Molecular Formula:C₂₂H₁₃ClF₃N₅O₃
Molecular Weight:487.825
Hs Code.:

Synonyms:2-chloro-5-[3,6-dihydro-6-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-2(1H)-yl]benzoic acid

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Chemical Property of 2-chloro-5-[3,6-dihydro-6-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-2(1H)-yl]benzoic acid

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Technology Process of 2-chloro-5-[3,6-dihydro-6-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-2(1H)-yl]benzoic acid

There total 9 articles about 2-chloro-5-[3,6-dihydro-6-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-2(1H)-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: C₇H₆ClN₂O₂^(1-)*Na⁽¹⁺⁾

: 635324-58-2
ethyl 4-chloro-1-methyl-6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 635325-28-9
2-chloro-5-[3,6-dihydro-6-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-2(1H)-yl]benzoic acid

Guidance literature:: C₇H₆ClN₂O₂^(1-)*Na⁽¹⁺⁾; ethyl 4-chloro-1-methyl-6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate; With sodium t-butanolate; In ethylene glycol; at 120 - 125 ℃; for 17 - 18h;

With hydrogenchloride; In water; ethylene glycol; at 20 ℃;

Reference yield: 42.0%

: 635324-58-2
ethyl 4-chloro-1-methyl-6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 184163-49-3
2-chloro-5-hydrazinobenzoic acid hydrochloride

: 635325-28-9
2-chloro-5-[3,6-dihydro-6-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-2(1H)-yl]benzoic acid

Guidance literature:: With sodium t-butanolate; In ethylene glycol; at 125 ℃; for 18h;
DOI:10.1016/S0968-0896(03)00183-4

Reference yield: 31.0%

: 184163-49-3
2-chloro-5-hydrazinylbenzoic acid hydrochloride

: 635324-58-2
ethyl 4-chloro-1-methyl-6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 635325-28-9
2-chloro-5-[3,6-dihydro-6-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-2(1H)-yl]benzoic acid

Guidance literature:: 2-chloro-5-hydrazinylbenzoic acid hydrochloride; With sodium t-butanolate; In ethylene glycol; at 75 ℃; for 1.5h;

ethyl 4-chloro-1-methyl-6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate; In ethylene glycol; tert-butyl alcohol; at 100 ℃; for 30h;
DOI:10.1021/acs.jmedchem.9b00858