184163-49-3Relevant articles and documents
Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 as a strategy for treatment of multiple myeloma
Hayes, Karen E.,Batsomboon, Paratchata,Chen, Wei-Chih,Johnson, Brennan D.,Becker, Andreas,Eschrich, Steven,Yang, Yan,Robart, Aaron R.,Dudley, Gregory B.,Geldenhuys, Werner J.,Hazlehurst, Lori A.
, p. 1479 - 1488 (2019)
Multiple myeloma (MM) cells demonstrate high basal endoplasmic reticulum (ER) stress and are typically exquisitely sensitive to agents such as proteasome inhibitors that activate the unfolded protein response. The flavin adenosine dinucleotide (FAD) conta
Dihydrodipyrazolopyridinylbenzamide and -sulfonamide inhibitors of B7-1
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Page/Page column 8, (2010/02/05)
The present invention provides a compound of formula I and the use thereof for the immunotherapeutic treatment of transplant rejection or autoimmune disease.
Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
The invention relates to new substituted 1-phenyl-3-pyrazolecarboxamides having a great affinity for human neurotensin receptors, to a process for preparing them and to pharmaceutical compositions containing them as active principles. More particularly, this invention relates to the discovery that the affinity for neurotensin receptors, especially human neurotensin receptors, is increased by substituting the phenyl group of 1-phenyl-3-pyrazolecarboxamide compounds with particular groups.