methyl 2-((2-fluorophenyl)amino)-2-(4-(trifluoromethyl)phenyl)acetate

Base Information

• Chemical Name: methyl 2-((2-fluorophenyl)amino)-2-(4-(trifluoromethyl)phenyl)acetate
• CAS No.: 1210858-96-0
• Molecular Formula: C₁₆H₁₃F₄NO₂
• Molecular Weight: 327.278
• Mol file: 1210858-96-0.mol

Synonyms:methyl 2-((2-fluorophenyl)amino)-2-(4-(trifluoromethyl)phenyl)acetate

Chemical Property of methyl 2-((2-fluorophenyl)amino)-2-(4-(trifluoromethyl)phenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((2-fluorophenyl)amino)-2-(4-(trifluoromethyl)phenyl)acetate

There total 4 articles about methyl 2-((2-fluorophenyl)amino)-2-(4-(trifluoromethyl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-Fluoroaniline (348-54-9) + α-bromo-(4-(trifluoromethyl)phenyl)acetic acid methyl ester (77053-53-3) → methyl 2-((2-fluorophenyl)amino)-2-(4-(trifluoromethyl)phenyl)acetate (1210858-96-0)

Guidance literature:

In acetonitrile; Reflux;

Reference yield: 85.0%

2-Fluoroaniline (348-54-9) + methyl 4-trifluoromethylphenyldiazoacetate (219564-85-9) → methyl 2-((2-fluorophenyl)amino)-2-(4-(trifluoromethyl)phenyl)acetate (1210858-96-0)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 50 ℃; for 0.17h; Schlenk technique;

DOI:10.1021/acs.joc.0c02588

Reference yield:

4-Trifluoromethylphenylacetic acid (32857-62-8) → methyl 2-((2-fluorophenyl)amino)-2-(4-(trifluoromethyl)phenyl)acetate (1210858-96-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 16 h / 20 °C

2: N-Bromosuccinimide; hydrogen bromide / water; tetrachloromethane / 2 h / Reflux

3: acetonitrile / 16 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; hydrogen bromide; In tetrachloromethane; water; acetonitrile;

DOI:10.1016/j.bmcl.2013.01.062

upstream raw materials:

2-Fluoroaniline

α-bromo-(4-(trifluoromethyl)phenyl)acetic acid methyl ester

4-Trifluoromethylphenylacetic acid

methyl 2-(4-(trifluoromethyl)phenyl)acetate

Downstream raw materials:

(2-Fluoro-phenylamino)-(4-trifluoromethyl-phenyl)-acetic acid

C₂₅H₂₁F₅N₂O

C₂₅H₂₁F₅N₂O

C₂₅H₂₂F₄N₂O