5-(4-chlorophenyl)-3,4-dihydro-2-(chloromethyl)-4-oxothieno-[2,3-d]pyrimidine-6-carboxamide

Base Information

• Chemical Name: 5-(4-chlorophenyl)-3,4-dihydro-2-(chloromethyl)-4-oxothieno-[2,3-d]pyrimidine-6-carboxamide
• CAS No.: 1335000-80-0
• Molecular Formula: C₁₄H₉Cl₂N₃O₂S
• Molecular Weight: 354.216
• Mol file: 1335000-80-0.mol

Synonyms:5-(4-chlorophenyl)-3,4-dihydro-2-(chloromethyl)-4-oxothieno-[2,3-d]pyrimidine-6-carboxamide

Chemical Property of 5-(4-chlorophenyl)-3,4-dihydro-2-(chloromethyl)-4-oxothieno-[2,3-d]pyrimidine-6-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-chlorophenyl)-3,4-dihydro-2-(chloromethyl)-4-oxothieno-[2,3-d]pyrimidine-6-carboxamide

There total 3 articles about 5-(4-chlorophenyl)-3,4-dihydro-2-(chloromethyl)-4-oxothieno-[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-amino-3-(4-chlorophenyl)thiophene-2,4-dicarboxamide (1335000-74-2) + chloroacetyl chloride (79-04-9) → 5-(4-chlorophenyl)-3,4-dihydro-2-(chloromethyl)-4-oxothieno-[2,3-d]pyrimidine-6-carboxamide (1335000-80-0)

Guidance literature:

With acetic acid; at 115 ℃;

DOI:10.1016/j.ejmech.2011.06.001

Reference yield:

5-amino-3-(4-chlorophenyl)thiophene-2,4-dicarbonitrile (139260-20-1) → 5-(4-chlorophenyl)-3,4-dihydro-2-(chloromethyl)-4-oxothieno-[2,3-d]pyrimidine-6-carboxamide (1335000-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 20 °C

1.2: Cooling with ice

2.1: acetic acid / 115 °C

With sulfuric acid; acetic acid;

DOI:10.1016/j.ejmech.2011.06.001

Reference yield:

p-chlorobenzoylacetonitrile (4640-66-8) → 5-(4-chlorophenyl)-3,4-dihydro-2-(chloromethyl)-4-oxothieno-[2,3-d]pyrimidine-6-carboxamide (1335000-80-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfur

2.1: sulfuric acid / 20 °C

2.2: Cooling with ice

3.1: acetic acid / 115 °C

With sulfuric acid; sulfur; acetic acid; 1.1: Gewald reaction;

DOI:10.1016/j.ejmech.2011.06.001

upstream raw materials:

5-amino-3-(4-chlorophenyl)thiophene-2,4-dicarbonitrile

5-amino-3-(4-chlorophenyl)thiophene-2,4-dicarboxamide

chloroacetyl chloride

p-chlorobenzoylacetonitrile