(R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)-N-methylethanamine

Base Information

Chemical Name:(R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)-N-methylethanamine
CAS No.:1453070-47-7
Molecular Formula:C₁₃H₁₈F₃N
Molecular Weight:245.288
Hs Code.:

Synonyms:(R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)-N-methylethanamine

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Chemical Property of (R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)-N-methylethanamine

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Technology Process of (R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)-N-methylethanamine

There total 9 articles about (R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)-N-methylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1453070-46-6
(S)-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

: 1453070-47-7
(R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)-N-methylethanamine

Guidance literature:: With hydrogenchloride; In methanol; for 1h; Inert atmosphere;

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1453070-47-7
(R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)-N-methylethanamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

4.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

5.1: dichloromethane; tetrahydrofuran / 2 h / -40 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -60 °C / Inert atmosphere

6.2: 1 h / -60 - 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

8.1: palladium on activated charcoal; hydrogen / methanol / 24 h / 20 °C / 2585.81 Torr / Inert atmosphere

With titanium(IV) isopropylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; palladium on activated charcoal; hydrogen; diisobutylaluminium hydride; triethylamine; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 880652-44-8
3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide

: 1453070-47-7
(R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)-N-methylethanamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

2.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

3.1: dichloromethane; tetrahydrofuran / 2 h / -40 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -60 °C / Inert atmosphere

4.2: 1 h / -60 - 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

6.1: palladium on activated charcoal; hydrogen / methanol / 24 h / 20 °C / 2585.81 Torr / Inert atmosphere

7.1: hydrogenchloride / methanol / 1 h / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; toluene;