(1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Base Information

Chemical Name:(1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide
CAS No.:1453070-48-8
Molecular Formula:C₃₄H₄₂F₃N₃O₂
Molecular Weight:581.722
Hs Code.:

(1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Synonyms:(1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Chemical Property of (1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Technology Process of (1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

There total 17 articles about (1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1453069-67-4
(1S,8aS)-7,7-diallyl-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-6(7H)-one

: 1453070-47-7
(R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)-N-methylethanamine

: 1453070-48-8
(1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: bis(trichloromethyl) carbonate; (1S,8aS)-7,7-diallyl-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-6(7H)-one; With dmap; triethylamine; In ethyl acetate; at 0 ℃; for 1.5h;

(R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)-N-methylethanamine; With triethylamine; In ethyl acetate; at 50 ℃; for 48h;

Reference yield:

: 880652-44-8
3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide

: 1453070-48-8
(1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

2.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

3.1: dichloromethane; tetrahydrofuran / 2 h / -40 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -60 °C / Inert atmosphere

4.2: 1 h / -60 - 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

6.1: palladium on activated charcoal; hydrogen / methanol / 24 h / 20 °C / 2585.81 Torr / Inert atmosphere

7.1: hydrogenchloride / methanol / 1 h / Inert atmosphere

8.1: triethylamine; dmap / ethyl acetate / 1.5 h / 0 °C

8.2: 48 h / 50 °C

With titanium(IV) isopropylate; hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; diisobutylaluminium hydride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 958258-15-6
3-bromo-5-(trifluoromethyl)benzoyl chloride

: 1453070-48-8
(1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloromethane / 1 h / 0 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

3.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

4.1: dichloromethane; tetrahydrofuran / 2 h / -40 - 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -60 °C / Inert atmosphere

5.2: 1 h / -60 - 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

7.1: palladium on activated charcoal; hydrogen / methanol / 24 h / 20 °C / 2585.81 Torr / Inert atmosphere

8.1: hydrogenchloride / methanol / 1 h / Inert atmosphere

9.1: triethylamine; dmap / ethyl acetate / 1.5 h / 0 °C

9.2: 48 h / 50 °C

With titanium(IV) isopropylate; hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; diisobutylaluminium hydride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene;