(+/-)-7-chloro-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-3-ethoxycarbonyl-4-oxoquinoline

Base Information

Chemical Name:(+/-)-7-chloro-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-3-ethoxycarbonyl-4-oxoquinoline
CAS No.:103477-54-9
Molecular Formula:C₂₁H₁₇ClFNO₃
Molecular Weight:385.822
Hs Code.:

Synonyms:(+/-)-7-chloro-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-3-ethoxycarbonyl-4-oxoquinoline

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Chemical Property of (+/-)-7-chloro-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-3-ethoxycarbonyl-4-oxoquinoline

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Technology Process of (+/-)-7-chloro-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-3-ethoxycarbonyl-4-oxoquinoline

There total 4 articles about (+/-)-7-chloro-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-3-ethoxycarbonyl-4-oxoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 103477-53-8
(+/-)-ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-<(2'-trans-phenylcyclopropyl)amino>acrylate

: 103477-54-9
(+/-)-7-chloro-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-3-ethoxycarbonyl-4-oxoquinoline

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 70 ℃; for 4h;
DOI:10.1021/jm00160a042

Reference yield:

: 155-09-9
trans-2-phenylcyclopropylamine

: 103477-54-9
(+/-)-7-chloro-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-3-ethoxycarbonyl-4-oxoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 0.5 h / Ambient temperature

2: 74 percent / NaH / tetrahydrofuran / 4 h / 70 °C

With sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00160a042

Reference yield:

: 86483-51-4
ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate

: 103477-54-9
(+/-)-7-chloro-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-3-ethoxycarbonyl-4-oxoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: acetic anhydride / 2 h / 110 °C

2: CH₂Cl₂ / 0.5 h / Ambient temperature

3: 74 percent / NaH / tetrahydrofuran / 4 h / 70 °C

With acetic anhydride; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00160a042