86483-51-4

Basic information

• Product Name: ETHYL 2,4-DICHLORO-5-FLUOROBENZOYLACETATE
• Synonyms: ETHYL 2,4-DICHLORO-5-FLUOROBENZOYLACETATE;ETHYL 2-(2,4-DICHLORO-5-FLUOROBENZOYL)ACETATE;3-(2,4-DICHLORO-5-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER;Ethyl2,4-dichoro-5-fluoro-oxo-benzenepropanoate;Ethyl 2-(2,4-dichloro-5-fluorophenyl)-2-oxoacetate;Ethyl 3-(2,4-dichloro-5-fluorophenyl)-3-oxopropanoate 97%;Benzenepropanoic acid,2,4-dichloro-5-fluoro-b-oxo-, ethyl ester
• CAS NO: 86483-51-4
• Molecular Formula: C₁₁H₉Cl₂FO₃
• Molecular Weight: 279.09
• Product Categories: Benzoic acid
• Mol File: 86483-51-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 329.5 °C at 760 mmHg
• Flash Point: 127.6 °C
• Appearance: /
• Density: 1.381 g/cm³
• Vapor Pressure: 0.000177mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: ETHYL 2,4-DICHLORO-5-FLUOROBENZOYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DICHLORO-5-FLUOROBENZOYLACETATE(86483-51-4)
• EPA Substance Registry System: ETHYL 2,4-DICHLORO-5-FLUOROBENZOYLACETATE(86483-51-4)

Safety Data

• Hazard Codes: Xi,F
• Hazardous Substances Data: 86483-51-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 28, p. 1558, 1985 DOI: 10.1021/jm00149a003

InChI:InChI=1/C11H9Cl2FO3/c1-2-17-11(16)5-10(15)6-3-9(14)8(13)4-7(6)12/h3-4H,2,5H2,1H3

Upstream product

• 86483-50-3 diethyl 2,4-dichloro-5-fluoro-benzoyl-malonate 
• 704-10-9 2,4-dichloro-5-fluoroacetophenone 
• 105-58-8 Diethyl carbonate 
• 86393-34-2 2,4-dichloro-5-fluorobenzoyl chloride 

Downstream Products

• 116588-72-8 8-fluoro-9-chloro-1,2,3,4-tetrahydro-6H-6-oxopyrido<1,2-a>quinoline-5-carboxylic acid 
• 116588-69-3 methyl 2-(2,4-dichloro-5-fluorobenzoyl)-2-(2-piperidylidene)-acetate 
• 116588-68-2 ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-2-(2-piperidylidene)-acetate 
• 116588-71-7 methyl 8-fluoro-9-chloro-1,2,3,4-tetrahydro-6H-6-oxopyrido<1,2-a>quinoline-5-carboxylate 
• 116588-70-6 ethyl 8-fluoro-9-chloro-1,2,3,4-tetrahydro-6H-6-oxopyrido<1,2-a>quinoline-5-carboxylate 
• 129527-46-4 ethyl 2,4-dichloro-5-fluoro-α-(2,4-difluorophenylhydrazono)benzoylacetate 
• 114610-30-9 ethyl 2,4-dichloro-5-fluoro-α-(4-fluorophenylhydrazono)benzoylacetate 
• 86393-37-5 amifloxacin 
• 88569-39-5 6-fluoro-7-chloro-1-methylamino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 88569-34-0 ethyl 1-(N-formyl-N-methyl)amino-6-fluoro-7-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 182627-55-0 (Z)-3-[4-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-butylamino]-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester 
• 182627-53-8 (Z)-3-[4-(6-Amino-purin-9-yl)-butylamino]-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester 
• 182627-52-7 (Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butylamino]-acrylic acid ethyl ester 
• 182627-54-9 (Z)-3-[4-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-butylamino]-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester 

Relevant articles and documents

ANTIVIRAL AND ANTIMICROBIAL COMPOUNDS

Disclosed are guanidine and biguanidine derivatives which have anti-viral and antibacterial activity. Also disclosed are pharmaceutical compositions containing such compounds as an active ingredient, and anti-viral and anti-bacterial methods utilizing such compounds. Methods of treating infections using the guanidine and biguanidine derivatives are also disclosed.

Pyridinyl-quinolone compounds, their preparation and use

Fluorinated 1-cyclopropyl-7-(substituted-pyridinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids of the formula STR1 wherein R is hydrogen, R' and R" are hydrogen or fluoro, or other groups and Z is 3- or 4-pyridinyl substituted by alkyl groups or substituted alkyl groups, are superior antibacterial agents. They are prepared via a coupling reaction between the corresponding esters (R=alkyl) having a halo group in the 7-position and a substituted (trialkylstannyl)pyridine.

Cycloaracylation of Enamines, I. - Synthesis of 4-Quinolone-3-carboxylic Acids

Starting with o-halobenzoyl chlorides 4 and open-chain secondary enamines 5, a new synthesis of 4-quinolone-3-carboxylic acids 12 is described.The reaction of 7-haloquinolone-3-carboxylic acids 12a-k with aliphatic amines 14 produces highly active antibacterial 7-aminoquinolone-3-carboxylic acids 15.The main product of the 1-cyclopropyl series, "ciprofloxacin" (15a), is being developed as a broad-spectrum chemotherapeutic agent.