methyl 1-(4-(2,3-dihydro-1H-perimidin-2-yl)benzoyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:methyl 1-(4-(2,3-dihydro-1H-perimidin-2-yl)benzoyl)pyrrolidine-2-carboxylate
CAS No.:1620891-25-9
Molecular Formula:C₂₄H₂₃N₃O₃
Molecular Weight:401.465
Hs Code.:

Synonyms:methyl 1-(4-(2,3-dihydro-1H-perimidin-2-yl)benzoyl)pyrrolidine-2-carboxylate

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Chemical Property of methyl 1-(4-(2,3-dihydro-1H-perimidin-2-yl)benzoyl)pyrrolidine-2-carboxylate

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Technology Process of methyl 1-(4-(2,3-dihydro-1H-perimidin-2-yl)benzoyl)pyrrolidine-2-carboxylate

There total 4 articles about methyl 1-(4-(2,3-dihydro-1H-perimidin-2-yl)benzoyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 315230-87-6
2-(4-carboxyphenyl)-2,3-dihydro-1H-perimidine

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 1620891-25-9
methyl 1-(4-(2,3-dihydro-1H-perimidin-2-yl)benzoyl)pyrrolidine-2-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 40 ℃; Inert atmosphere;
DOI:10.3390/molecules19010102

Reference yield:

: 307330-12-7
ZIN⁽⁰²⁸⁾C₀₀₆₇₆

: 1620891-25-9
methyl 1-(4-(2,3-dihydro-1H-perimidin-2-yl)benzoyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

With dmap; lithium hydroxide monohydrate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.3390/molecules19010102

Reference yield:

: 479-27-6
naphthalene-1,8-diamine

: 1620891-25-9
methyl 1-(4-(2,3-dihydro-1H-perimidin-2-yl)benzoyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: zinc acetate hydrate / methanol / 16 h / 20 °C / Inert atmosphere

2: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

With dmap; lithium hydroxide monohydrate; zinc acetate hydrate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.3390/molecules19010102