Methanesulfonic acid (E)-1,1-difluoro-2-phenethyl-but-2-enyl ester

Base Information

• Chemical Name: Methanesulfonic acid (E)-1,1-difluoro-2-phenethyl-but-2-enyl ester
• CAS No.: 335239-85-5
• Molecular Formula: C₁₃H₁₆F₂O₃S
• Molecular Weight: 290.331
• Mol file: 335239-85-5.mol

Synonyms:Methanesulfonic acid (E)-1,1-difluoro-2-phenethyl-but-2-enyl ester

Chemical Property of Methanesulfonic acid (E)-1,1-difluoro-2-phenethyl-but-2-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (E)-1,1-difluoro-2-phenethyl-but-2-enyl ester

There total 3 articles about Methanesulfonic acid (E)-1,1-difluoro-2-phenethyl-but-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-pentan-3-one (335239-70-8) → Methanesulfonic acid (E)-1,1-difluoro-2-phenethyl-but-2-enyl ester (335239-85-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / HMPT / tetrahydrofuran

2: TBAF / tetrahydrofuran

3: Et₃N / CH₂Cl₂

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol007060u

Reference yield:

tert-butyl-(3,3-difluoro-1-methyl-2-phenethyl-allyloxy)-dimethyl-silane (335239-78-6) → Methanesulfonic acid (E)-1,1-difluoro-2-phenethyl-but-2-enyl ester (335239-85-5)

Guidance literature:

Multi-step reaction with 2 steps

1: TBAF / tetrahydrofuran

2: Et₃N / CH₂Cl₂

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol007060u

Reference yield:

methanesulfonyl chloride (124-63-0) + 3-Difluoromethylene-5-phenyl-pentan-2-ol (1027178-82-0) → Methanesulfonic acid (E)-1,1-difluoro-2-phenethyl-but-2-enyl ester (335239-85-5)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/ol007060u

upstream raw materials:

methanesulfonyl chloride

3-Difluoromethylene-5-phenyl-pentan-2-ol

4-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-pentan-3-one

tert-butyl-(3,3-difluoro-1-methyl-2-phenethyl-allyloxy)-dimethyl-silane

Downstream raw materials:

(E)-2-(2-phenylethyl)but-2-enoyl fluoride