Technology Process of N-(1-carboxyethyl)-alpha-(2-phenylethyl)glycyl-leucine, N-phenylamide
There total 4 articles about N-(1-carboxyethyl)-alpha-(2-phenylethyl)glycyl-leucine, N-phenylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium dihydroxide;
In
methanol;
for 3h;
under 760 Torr;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 6.40 g / NaBH3CN, AcOH, pyridine / tetrahydrofuran / 0 °C
2: HCl(gas) / ethyl acetate / 7 h / 50 °C
3: 8.31 g / HOBt, NMM, EDC / dimethylformamide / 16 h / Ambient temperature
4: 6.50 g / H2 / Pearlman's catalyst / methanol / 3 h / 760 Torr
With
4-methyl-morpholine; pyridine; hydrogenchloride; hydrogen; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: HCl(gas) / ethyl acetate / 7 h / 50 °C
2: 8.31 g / HOBt, NMM, EDC / dimethylformamide / 16 h / Ambient temperature
3: 6.50 g / H2 / Pearlman's catalyst / methanol / 3 h / 760 Torr
With
4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
palladium dihydroxide;
In
methanol; ethyl acetate; N,N-dimethyl-formamide;