N,N-dimethyl-[6-bromo-9-(2-chloro-5-trifluoromethyl benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine

Base Information

Chemical Name:N,N-dimethyl-[6-bromo-9-(2-chloro-5-trifluoromethyl benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine
CAS No.:1414847-96-3
Molecular Formula:C₂₁H₁₉BrClF₃N₂O₂S
Molecular Weight:535.812
Hs Code.:

Synonyms:N,N-dimethyl-[6-bromo-9-(2-chloro-5-trifluoromethyl benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine

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Chemical Property of N,N-dimethyl-[6-bromo-9-(2-chloro-5-trifluoromethyl benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine

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Technology Process of N,N-dimethyl-[6-bromo-9-(2-chloro-5-trifluoromethyl benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine

There total 3 articles about N,N-dimethyl-[6-bromo-9-(2-chloro-5-trifluoromethyl benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186545-33-5
N,N-dimethyl-(6-bromo-2,3,4,9-tetrahydro-1H-carbazol-3-yl)amine

: 54090-08-3
2-chloro-5-trifluoromethyl-benzenesulfonyl chloride

: 1414847-96-3
N,N-dimethyl-[6-bromo-9-(2-chloro-5-trifluoromethyl benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine

Guidance literature:: N,N-dimethyl-(6-bromo-2,3,4,9-tetrahydro-1H-carbazol-3-yl)amine; With potassium hydride; In tetrahydrofuran; mineral oil; at 25 ℃; for 1h;

2-chloro-5-trifluoromethyl-benzenesulfonyl chloride; In tetrahydrofuran; mineral oil; at 25 ℃; for 2h;
DOI:10.1016/j.bmcl.2012.06.002

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1414847-96-3
N,N-dimethyl-[6-bromo-9-(2-chloro-5-trifluoromethyl benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: deuteromethanol / 2 h / 20 °C

1.2: 18 h / 25 - 30 °C / pH Ca_. 6

2.1: sulfuric acid / water / 95 - 100 °C

3.1: potassium hydride / tetrahydrofuran; mineral oil / 1 h / 25 °C

3.2: 2 h / 25 °C

With sulfuric acid; potassium hydride; In tetrahydrofuran; deuteromethanol; water; mineral oil;
DOI:10.1016/j.bmcl.2012.06.002

Reference yield:

: 176661-76-0
(1,4-dioxa-spiro[4.5]dec-8-yl)dimethylamine

: 1414847-96-3
N,N-dimethyl-[6-bromo-9-(2-chloro-5-trifluoromethyl benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / water / 95 - 100 °C

2.1: potassium hydride / tetrahydrofuran; mineral oil / 1 h / 25 °C

2.2: 2 h / 25 °C

With sulfuric acid; potassium hydride; In tetrahydrofuran; water; mineral oil;
DOI:10.1016/j.bmcl.2012.06.002