C₁₂H₁₆ClNOS

Base Information

• Chemical Name: C₁₂H₁₆ClNOS
• CAS No.: 1172578-24-3
• Molecular Formula: C₁₂H₁₆ClNOS
• Molecular Weight: 257.784
• Mol file: 1172578-24-3.mol

Synonyms:C₁₂H₁₆ClNOS

Chemical Property of C₁₂H₁₆ClNOS

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₂H₁₆ClNOS

There total 1 articles about C₁₂H₁₆ClNOS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → C12H16ClNOS (1172578-24-3)

Guidance literature:

With titanium(IV) tetraethanolate; In neat (no solvent); at 72 ℃; Inert atmosphere;

DOI:10.1021/jo4014386

Reference yield: 91.0%

C12H16ClNOS (1172578-24-3) + vinyl magnesium bromide (1826-67-1) → C14H19NOS + C14H19NOS (1309795-20-7) + (R(S))-N-(1-phenylethylidene)-tert-butanesulfinamide (212378-97-7)

Guidance literature:

C₁₂H₁₆ClNOS; vinyl magnesium bromide; In dichloromethane; at -78 - -40 ℃; for 6h;

With ammonium chloride; In dichloromethane; water; at -40 ℃;

DOI:10.1055/s-0030-1259554

Reference yield: 85.0%

C12H16ClNOS (1172578-24-3) + allylmagnesium bromide (2622-05-1) → (R(S),R)-1-(tert-butylsulfinyl)-2-allyl-2-phenylaziridine + (R(S),S)-1-(tert-butylsulfinyl)-2-allyl-2-phenylaziridine (1236324-91-6)

Guidance literature:

In dichloromethane; at -78 - 0 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1039/c001471k

upstream raw materials:

1-chloroacetophenone

(R)-2-methylpropane-2-sulfinamide

Downstream raw materials:

(R(S),S)-1-(tert-butylsulfinyl)-2-methyl-2-phenylaziridine

(R(S),S)-1-(tert-butylsulfinyl)-2-allyl-2-phenylaziridine

(R(S),S)-1-(tert-butylsulfinyl)-2-ethyl-2-phenylaziridine

(R_S,S)-N-(2-chloro-1-phenylethyl)-tert-butanesulfinamide