1-benzenesulfonyl-2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole

Base Information

Chemical Name:1-benzenesulfonyl-2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole
CAS No.:1346163-41-4
Molecular Formula:C₂₆H₂₁N₃O₅S₂
Molecular Weight:519.602
Hs Code.:

Synonyms:1-benzenesulfonyl-2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole

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Chemical Property of 1-benzenesulfonyl-2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole

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Technology Process of 1-benzenesulfonyl-2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole

There total 2 articles about 1-benzenesulfonyl-2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1346163-38-9
1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1346163-41-4
1-benzenesulfonyl-2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In ethanol; water; toluene; at 150 ℃; for 0.25h; Inert atmosphere; Sealed tube; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.08.048

Reference yield:

: 722538-29-6
1-benzenesulfonyl-6-methoxy-2-tributylstannyl-1H-indole

: 1346163-41-4
1-benzenesulfonyl-2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 0.25 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water; toluene; 1: Stille cross-coupling / 2: Suzuki cross-coupling;
DOI:10.1016/j.ejmech.2011.08.048

Reference yield: 99.0%

: 1346163-41-4
1-benzenesulfonyl-2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole

: 1346163-44-7
2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole

Guidance literature:: 1-benzenesulfonyl-2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole; With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 15h; Reflux;

With water;
DOI:10.1016/j.ejmech.2011.08.048