2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-1H-indol-6-ol

Base Information

• Chemical Name: 2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-1H-indol-6-ol
• CAS No.: 1346163-47-0
• Molecular Formula: C₁₉H₁₅N₃O₃S
• Molecular Weight: 365.412
• Mol file: 1346163-47-0.mol

Synonyms:2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-1H-indol-6-ol

Chemical Property of 2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-1H-indol-6-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-1H-indol-6-ol

There total 5 articles about 2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-1H-indol-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole (1346163-44-7) → 2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-1H-indol-6-ol (1346163-47-0)

Guidance literature:

2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole; With boron tribromide; In dichloromethane; at 0 - 20 ℃;

With water; In dichloromethane; Cooling with ice;

DOI:10.1016/j.ejmech.2011.08.048

Reference yield:

1-benzenesulfonyl-6-methoxy-2-tributylstannyl-1H-indole (722538-29-6) → 2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-1H-indol-6-ol (1346163-47-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 0.25 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / Reflux

4.1: boron tribromide / dichloromethane / 0 - 20 °C

4.2: Cooling with ice

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; boron tribromide; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 1.1: Stille cross-coupling / 2.1: Suzuki cross-coupling;

DOI:10.1016/j.ejmech.2011.08.048

Reference yield:

1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole (1346163-38-9) → 2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-1H-indol-6-ol (1346163-47-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 0.25 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / Reflux

3.1: boron tribromide / dichloromethane / 0 - 20 °C

3.2: Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; boron tribromide; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 1.1: Suzuki cross-coupling;

DOI:10.1016/j.ejmech.2011.08.048

upstream raw materials:

1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole

1-benzenesulfonyl-2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole

2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole

1-benzenesulfonyl-6-methoxy-2-tributylstannyl-1H-indole