6-<(4-acetyl-3-hydroxy-2-propylphenyl)-methoxy>-1,2,3,4-tetrahydro-N-<(2-methylphenyl)sulfonyl>-1-oxo-2-naphthaleneacetamide

Base Information

Chemical Name:6-<(4-acetyl-3-hydroxy-2-propylphenyl)-methoxy>-1,2,3,4-tetrahydro-N-<(2-methylphenyl)sulfonyl>-1-oxo-2-naphthaleneacetamide
CAS No.:135312-27-5
Molecular Formula:C₃₁H₃₃NO₇S
Molecular Weight:563.672
Hs Code.:

Synonyms:6-<(4-acetyl-3-hydroxy-2-propylphenyl)-methoxy>-1,2,3,4-tetrahydro-N-<(2-methylphenyl)sulfonyl>-1-oxo-2-naphthaleneacetamide

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Chemical Property of 6-<(4-acetyl-3-hydroxy-2-propylphenyl)-methoxy>-1,2,3,4-tetrahydro-N-<(2-methylphenyl)sulfonyl>-1-oxo-2-naphthaleneacetamide

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Technology Process of 6-<(4-acetyl-3-hydroxy-2-propylphenyl)-methoxy>-1,2,3,4-tetrahydro-N-<(2-methylphenyl)sulfonyl>-1-oxo-2-naphthaleneacetamide

There total 5 articles about 6-<(4-acetyl-3-hydroxy-2-propylphenyl)-methoxy>-1,2,3,4-tetrahydro-N-<(2-methylphenyl)sulfonyl>-1-oxo-2-naphthaleneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 88-19-7
methyl 2-(aminosulfonyl)benzoate

: 119348-58-2
6-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid

: 135312-27-5
6-<(4-acetyl-3-hydroxy-2-propylphenyl)-methoxy>-1,2,3,4-tetrahydro-N-<(2-methylphenyl)sulfonyl>-1-oxo-2-naphthaleneacetamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 40h; Ambient temperature;
DOI:10.1021/jm00113a014

Reference yield:

: 50558-96-8
6-methoxy-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid, ethyl ester

: 135312-27-5
6-<(4-acetyl-3-hydroxy-2-propylphenyl)-methoxy>-1,2,3,4-tetrahydro-N-<(2-methylphenyl)sulfonyl>-1-oxo-2-naphthaleneacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 33 percent / AlCl₃ / CH₂Cl₂ / 20 h / Heating

2: 76 percent / potassium t-butoxide, NaI / ethanol / 30 h / Ambient temperature

3: 44 percent / 5 N NaOH / ethanol / 2 h / Heating

4: 79 percent / 4-(dimethylamino)pyridine, DCC / CH₂Cl₂ / 40 h / Ambient temperature

With dmap; sodium hydroxide; aluminium trichloride; potassium tert-butylate; dicyclohexyl-carbodiimide; sodium iodide; In ethanol; dichloromethane;
DOI:10.1021/jm00113a014

Reference yield:

: 105806-38-0
6-hydroxy-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid ethyl ester

: 135312-27-5
6-<(4-acetyl-3-hydroxy-2-propylphenyl)-methoxy>-1,2,3,4-tetrahydro-N-<(2-methylphenyl)sulfonyl>-1-oxo-2-naphthaleneacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / potassium t-butoxide, NaI / ethanol / 30 h / Ambient temperature

2: 44 percent / 5 N NaOH / ethanol / 2 h / Heating

3: 79 percent / 4-(dimethylamino)pyridine, DCC / CH₂Cl₂ / 40 h / Ambient temperature

With dmap; sodium hydroxide; potassium tert-butylate; dicyclohexyl-carbodiimide; sodium iodide; In ethanol; dichloromethane;
DOI:10.1021/jm00113a014