tert-butyl 4-(5-((4-((2-(1-(methoxycarbonyl)cyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino) pyridin-2-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(5-((4-((2-(1-(methoxycarbonyl)cyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino) pyridin-2-yl)piperidine-1-carboxylate
CAS No.:1566543-80-3
Molecular Formula:C₃₃H₃₄F₃N₅O₄
Molecular Weight:621.659
Hs Code.:

tert-butyl 4-(5-((4-((2-(1-(methoxycarbonyl)cyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino) pyridin-2-yl)piperidine-1-carboxylate

Synonyms:tert-butyl 4-(5-((4-((2-(1-(methoxycarbonyl)cyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino) pyridin-2-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(5-((4-((2-(1-(methoxycarbonyl)cyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino) pyridin-2-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(5-((4-((2-(1-(methoxycarbonyl)cyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino) pyridin-2-yl)piperidine-1-carboxylate

There total 8 articles about tert-butyl 4-(5-((4-((2-(1-(methoxycarbonyl)cyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino) pyridin-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1566543-58-5
tert-butyl 4-(5-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

: 1566543-55-2
methyl 1-(2-ethynylphenyl)cyclopropanecarboxylate

: 1566543-80-3
tert-butyl 4-(5-((4-((2-(1-(methoxycarbonyl)cyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino) pyridin-2-yl)piperidine-1-carboxylate

Guidance literature:: tert-butyl 4-(5-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate; methyl 1-(2-ethynylphenyl)cyclopropanecarboxylate; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

With triethylamine; In N,N-dimethyl-formamide; at 120 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 885693-47-0
tert-butyl 5-nitro-5’,6’-dihydro-[2,4‘-bipyridine]-1‘(2’H)-carboxylate

: 1566543-80-3
tert-butyl 4-(5-((4-((2-(1-(methoxycarbonyl)cyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino) pyridin-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.33 h / 20 °C

2.2: 44 h / 20 °C

3.1: triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

3.2: 0.33 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; triphenylphosphine; zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 885693-48-1
5-amino-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridinyl)-1'-carboxylic acid tert-butyl ester

: 1566543-80-3
tert-butyl 4-(5-((4-((2-(1-(methoxycarbonyl)cyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino) pyridin-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.33 h / 20 °C

1.2: 44 h / 20 °C

2.1: triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 0.33 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;