1-(2-(2-(2-((6-(1-methylpiperidin-4-yl)pyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Base Information

Chemical Name:1-(2-(2-(2-((6-(1-methylpiperidin-4-yl)pyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide
CAS No.:1566543-43-8
Molecular Formula:C₂₈H₃₁F₃N₆O
Molecular Weight:524.589
Hs Code.:

Synonyms:1-(2-(2-(2-((6-(1-methylpiperidin-4-yl)pyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Chemical Property of 1-(2-(2-(2-((6-(1-methylpiperidin-4-yl)pyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Technology Process of 1-(2-(2-(2-((6-(1-methylpiperidin-4-yl)pyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

There total 14 articles about 1-(2-(2-(2-((6-(1-methylpiperidin-4-yl)pyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1566542-80-0
1-(2-(2-(2-((6-(piperidin-4-yl)pyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

: 1566543-43-8
1-(2-(2-(2-((6-(1-methylpiperidin-4-yl)pyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: With sodium tris(acetoxy)borohydride; In methanol; water; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 885693-47-0
tert-butyl 5-nitro-5’,6’-dihydro-[2,4‘-bipyridine]-1‘(2’H)-carboxylate

: 1566543-43-8
1-(2-(2-(2-((6-(1-methylpiperidin-4-yl)pyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.33 h / 20 °C

2.2: 44 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / 1,4-dioxane / 4 h / 85 °C

4.1: hydrogen; palladium 10% on activated carbon; triethylamine / N,N-dimethyl-formamide / 20 h

5.1: trifluoroacetic acid / dichloromethane / 7 h

6.1: sodium tris(acetoxy)borohydride / water; methanol / 3 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; trifluoroacetic acid; zinc(II) chloride; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 885693-48-1
5-amino-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridinyl)-1'-carboxylic acid tert-butyl ester

: 1566543-43-8
1-(2-(2-(2-((6-(1-methylpiperidin-4-yl)pyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.33 h / 20 °C

1.2: 44 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / 1,4-dioxane / 4 h / 85 °C

3.1: hydrogen; palladium 10% on activated carbon; triethylamine / N,N-dimethyl-formamide / 20 h

4.1: trifluoroacetic acid / dichloromethane / 7 h

5.1: sodium tris(acetoxy)borohydride / water; methanol / 3 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; trifluoroacetic acid; zinc(II) chloride; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;