2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid

Base Information

• Chemical Name: 2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid
• CAS No.: 1448870-05-0
• Molecular Formula: C₂₁H₁₉BrClN₅O₃
• Molecular Weight: 504.771
• Mol file: 1448870-05-0.mol

Synonyms:2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid

Chemical Property of 2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid

There total 7 articles about 2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1 H-imidazole-4-carboxylic acid ethyl ester (1448870-06-1) → 2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid (1448870-05-0)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

2-bromo-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester (1448869-67-7) → 2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid (1448870-05-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 - 70 °C / Inert atmosphere

1.2: 1.5 h / -78 - -20 °C / Inert atmosphere

2.1: Methanesulfonic anhydride; triethylamine / dichloromethane / 0.25 h / 5 °C / Inert atmosphere

2.2: 48 h / 5 - 20 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran; water / 0.5 h / 20 °C / Inert atmosphere

With triethylamine; sodium hydroxide; lithium diisopropyl amide; Methanesulfonic anhydride; In tetrahydrofuran; dichloromethane; water;

Reference yield:

2-bromo-5-[(4-cyano-phenyl)-hydroxy-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester (1448869-83-7) → 2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid (1448870-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Methanesulfonic anhydride; triethylamine / dichloromethane / 0.25 h / 5 °C / Inert atmosphere

1.2: 48 h / 5 - 20 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water / 0.5 h / 20 °C / Inert atmosphere

With triethylamine; sodium hydroxide; Methanesulfonic anhydride; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1 H-imidazole-4-carboxylic acid ethyl ester

2-bromo-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

2-bromo-5-[(4-cyano-phenyl)-hydroxy-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

5-amino-3-chloro-1-methyl-1H-pyridin-2-one

Downstream raw materials:

4-[5-(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-3-isopropyl-6-oxo-3,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-4-yl]-benzonitrile

4-[5-(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3-isopropyl-2-(4-methoxy-2-methylamino-pyrimidin-5-yl)-6-oxo-3,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-4-yl]-benzonitrile

4-[2-(2-amino-4-methoxy-pyrimidin-5-yl)-5-(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3-isopropyl-6-oxo-3,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-4-yl]-benzonitrile