Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1448869-67-7

Post Buying Request

1448869-67-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1448869-67-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1448869-67-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,8,8,6 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1448869-67:
(9*1)+(8*4)+(7*4)+(6*8)+(5*8)+(4*6)+(3*9)+(2*6)+(1*7)=227
227 % 10 = 7
So 1448869-67-7 is a valid CAS Registry Number.

1448869-67-7Downstream Products

1448869-67-7Relevant articles and documents

IMIDAXOPYROLONE COMPOUND AND APPLICATION THEREOF

-

, (2021/01/28)

Disclosed is a novel class of MDM2-p53 inhibitor compounds having an imidaxopyrolone structure, and specifically disclosed are compounds represented by formulas (I-1) and (I-2) and pharmaceutically acceptable salts thereof. (I-1), (I-2)

In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor

Vaupel, Andrea,Holzer, Philipp,Ferretti, Stephane,Guagnano, Vito,Kallen, Joerg,Mah, Robert,Masuya, Keiichi,Ruetz, Stephan,Rynn, Caroline,Schlapbach, Achim,Stachyra, Thérèse,Stutz, Stefan,Todorov, Milen,Jeay, Sébastien,Furet, Pascal

, p. 3404 - 3408 (2018/09/17)

Small molecule inhibitors of the p53-MDM2 protein complex are under intense investigation in clinical trials as anti-cancer agents, including our first generation inhibitor NVP-CGM097. We recently described the rational design of a novel pyrazolopyrrolidinone core as a new lead structure and now we report on the synthesis and optimization of this to provide a highly potent lead compound. This new compound displayed excellent oral efficacy in our preclinical mechanistic in vivo model and marked a significant milestone towards the identification of our second generation clinical candidate NVP-HDM201.

SUBSTITUTED PURINONE COMPOUNDS

-

, (2014/08/07)

The invention relates to compounds of formula (I): (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1448869-67-7