2-benzyl-N-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide

Base Information

Chemical Name:2-benzyl-N-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide
CAS No.:1338562-28-9
Molecular Formula:C₁₅H₁₅N₃O₃
Molecular Weight:285.302
Hs Code.:

Synonyms:2-benzyl-N-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide

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Chemical Property of 2-benzyl-N-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide

Chemical Property:

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Technology Process of 2-benzyl-N-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide

There total 5 articles about 2-benzyl-N-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338563-21-5
ethyl 2-benzyl-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylate

: 1338562-28-9
2-benzyl-N-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide

Guidance literature:: With hydroxylamine hydrochloride; potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; sonicated;

Reference yield:

: 55942-40-0
1H-pyrrole-2,4-dicarboxylic acid diethyl ester

: 1338562-28-9
2-benzyl-N-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / Reflux

2.1: sodium azide / N,N-dimethyl-formamide / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 1551.49 Torr

3.2: Reflux

4.1: caesium carbonate / acetonitrile / 70 °C

5.1: hydroxylamine hydrochloride; potassium hydroxide / dimethyl sulfoxide / 20 °C / sonicated

With sodium azide; hydroxylamine hydrochloride; hydrogen; potassium carbonate; caesium carbonate; potassium hydroxide; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 163213-48-7
diethyl 1-(2-bromoethyl)pyrrole-2,4-dicarboxylate

: 1338562-28-9
2-benzyl-N-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / N,N-dimethyl-formamide / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 1551.49 Torr

2.2: Reflux

3.1: caesium carbonate / acetonitrile / 70 °C

4.1: hydroxylamine hydrochloride; potassium hydroxide / dimethyl sulfoxide / 20 °C / sonicated

With sodium azide; hydroxylamine hydrochloride; hydrogen; caesium carbonate; potassium hydroxide; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;