Technology Process of ethyl 2-benzyl-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylate
There total 5 articles about ethyl 2-benzyl-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
acetonitrile;
at 70 ℃;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydride / tert-butyl methyl ether / 4 h / 20 °C
2.1: potassium carbonate / acetonitrile / Reflux
3.1: sodium azide / N,N-dimethyl-formamide / 20 °C
4.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 1551.49 Torr
4.2: Reflux
5.1: caesium carbonate / acetonitrile / 70 °C
With
sodium azide; hydrogen; potassium hydride; potassium carbonate; caesium carbonate;
palladium 10% on activated carbon;
In
ethanol; tert-butyl methyl ether; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / Reflux
2.1: sodium azide / N,N-dimethyl-formamide / 20 °C
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 1551.49 Torr
3.2: Reflux
4.1: caesium carbonate / acetonitrile / 70 °C
With
sodium azide; hydrogen; potassium carbonate; caesium carbonate;
palladium 10% on activated carbon;
In
ethanol; N,N-dimethyl-formamide; acetonitrile;
![ethyl 1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylate](/Databaselist/images/loading.webp)
