toluene-4-sulfonic acid 5-bromo-2,4-dimethoxy-3-methyl-phenyl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 5-bromo-2,4-dimethoxy-3-methyl-phenyl ester
• CAS No.: 641627-83-0
• Molecular Formula: C₁₆H₁₇BrO₅S
• Molecular Weight: 401.278
• Mol file: 641627-83-0.mol

Synonyms:toluene-4-sulfonic acid 5-bromo-2,4-dimethoxy-3-methyl-phenyl ester

Chemical Property of toluene-4-sulfonic acid 5-bromo-2,4-dimethoxy-3-methyl-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of toluene-4-sulfonic acid 5-bromo-2,4-dimethoxy-3-methyl-phenyl ester

There total 3 articles about toluene-4-sulfonic acid 5-bromo-2,4-dimethoxy-3-methyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

toluene-4-sulfonic acid 2,4-dimethoxy-3-methyl-phenyl ester (641627-82-9) → toluene-4-sulfonic acid 5-bromo-2,4-dimethoxy-3-methyl-phenyl ester (641627-83-0)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; for 10.5h;

DOI:10.1021/ja039223q

Reference yield:

2,4-dimethoxy-3-methylphenol (19676-67-6) → toluene-4-sulfonic acid 5-bromo-2,4-dimethoxy-3-methyl-phenyl ester (641627-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / Et₃N / CH₂Cl₂ / 3.5 h / 20 °C

2: 84 percent / N-bromocussinimide / acetonitrile / 10.5 h

With N-Bromosuccinimide; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/ja039223q

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → toluene-4-sulfonic acid 5-bromo-2,4-dimethoxy-3-methyl-phenyl ester (641627-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / Et₃N / CH₂Cl₂ / 3.5 h / 20 °C

2: 84 percent / N-bromocussinimide / acetonitrile / 10.5 h

With N-Bromosuccinimide; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/ja039223q

upstream raw materials:

toluene-4-sulfonic acid 2,4-dimethoxy-3-methyl-phenyl ester

2,4-dimethoxy-3-methylphenol

p-toluenesulfonyl chloride

Downstream raw materials:

(1S,4S,5R,6R)-4-(5-Hydroxy-2,4-dimethoxy-3-methyl-benzyl)-2-oxo-6-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid benzyl ester

Toluene-4-sulfonic acid 2,4-dimethoxy-3-methyl-5-((1R,2S,5S,7R)-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-2-ylmethyl)-phenyl ester

Toluene-4-sulfonic acid 5-[(1R,2S,5S,7R)-7-hydroxymethyl-4-oxo-8-(toluene-4-sulfonyl)-3,8-diaza-bicyclo[3.2.1]oct-2-ylmethyl]-2,4-dimethoxy-3-methyl-phenyl ester

Toluene-4-sulfonic acid 5-[(1R,5S,7R)-8-benzyl-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-(2Z)-ylidenemethyl]-2,4-dimethoxy-3-methyl-phenyl ester