Technology Process of toluene-4-sulfonic acid 2,4-dimethoxy-3-methyl-phenyl ester
There total 1 articles about toluene-4-sulfonic acid 2,4-dimethoxy-3-methyl-phenyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 3.5h;
DOI:10.1021/ja039223q
- Guidance literature:
-
With
N-Bromosuccinimide;
In
acetonitrile;
for 10.5h;
DOI:10.1021/ja039223q
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 84 percent / N-bromocussinimide / acetonitrile / 10.5 h
2.1: n-BuLi / diethyl ether; hexane / 0.33 h / -78 °C
2.2: 84 percent / diethyl ether / 0.33 h / -78 - -40 °C
3.1: MeOH; aq. K2CO3; Pd(PPh3)4 / benzene / 3.5 h / 70 °C
4.1: CF3CO2H; H2 / Pd/C / ethanol / 28 h / 51714.8 Torr
5.1: N,N-dimethylaminopyridine / acetonitrile / 0.67 h
6.1: potassium trimethylsilanoate / acetonitrile / 1.5 h / 20 °C
7.1: N,N-dimethylaminopyridine / acetonitrile / 0.42 h / 20 °C
8.1: NaBH4 / ethanol / 1.75 h / 20 °C
9.1: AcCl / methanol / 9 h / 20 °C
With
methanol; dmap; sodium tetrahydroborate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; potassium trimethylsilonate; hydrogen; potassium carbonate; acetyl chloride; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; diethyl ether; ethanol; hexane; acetonitrile; benzene;
3.1: Suzuki coupling;
DOI:10.1021/ja039223q
